Xanthine dehydrogenase

Xanthine dehydrogenase, also known as XDH, is a protein that, in humans, is encoded by the ''XDH'' gene.

Function

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.

Xanthine dehydrogenase catalyzes the following chemical reaction:

xanthine + NAD⁺ + H₂O $\rightleftharpoons$ urate + NADH + H⁺

The three substrates of this enzyme are xanthine, NAD⁺, and H₂O, whereas its three products are urate, NADH, and H⁺.

This enzyme participates in purine metabolism.

Nomenclature

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on CH or CH₂ groups with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is xanthine:NAD⁺ oxidoreductase. Other names in common use include NAD⁺-xanthine dehydrogenase, xanthine-NAD⁺ oxidoreductase, xanthine/NAD⁺ oxidoreductase, and xanthine oxidoreductase.

Clinical significance

Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. It has been shown that patients with lung adenocarcinoma tumors which have high levels of XDH gene expression have lower survivals. Addiction to XDH protein has been used to target NSCLC tumors and cell lines in a precision oncology manner.

See also

* Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
* MOCOS
* Xanthine oxidase

References

Further reading

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External links

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EC 1.17.1
EC 1.17.3
NADH-dependent enzymes
Enzymes of known structure
Molybdenum enzymes
Metalloproteins
Genes on human chromosome 2