Consisting of about 110
amino acids, the domain in winged-helix transcription factors (see
Regulation of gene expression) has four helices and a two-strand
beta-sheet
The beta sheet, (β-sheet) (also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands) connected laterally by at least two or three backbone hydrogen bonds, forming a ge ...
.
These proteins are classified into 19 families called FoxA-FoxS.
Mutations in FoxP proteins are implicated in human
autoimmune diseases.
See also
*
FOX proteins
FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic ...
External links
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Transcription factors
{{Transcription factors, g3