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VIRULENCE is a pathogen or microbe's ability to infect or damage a host.

In the context of gene for gene systems, often in plants, virulence refers to a pathogen's ability to infect a resistant host. In most other contexts, especially in animal systems, virulence refers to the degree of damage caused by a microbe to its host . The pathogenicity of an organism - its ability to cause disease - is determined by its virulence factors . The noun virulence derives from the adjective virulent. Virulent can describe either disease severity or a pathogen's infectivity. The word virulent derives from the Latin word virulentus, meaning "a poisoned wound" or "full of poison."

In an ecological context, virulence can be defined as the host's parasite-induced loss of fitness . Virulence
Virulence
can be understood in terms of proximate causes —those specific traits of the pathogen that help make the host ill—and ultimate causes —the evolutionary pressures that lead to virulent traits occurring in a pathogen strain.

CONTENTS

* 1 Virulent bacteria

* 1.1 Methods by which bacteria cause disease

* 2 Virulent viruses * 3 Evolution * 4 See also * 5 References

VIRULENT BACTERIA

The ability of bacteria to cause disease is described in terms of the number of infecting bacteria, the route of entry into the body, the effects of host defense mechanisms, and intrinsic characteristics of the bacteria called virulence factors . Many virulence factors are so-called effector proteins that are injected into the host cells by special secretion machines such as the type 3 secretion system . Host-mediated pathogenesis is often important because the host can respond aggressively to infection with the result that host defense mechanisms do damage to host tissues while the infection is being countered.

The virulence factors of bacteria are typically proteins or other molecules that are synthesized by enzymes. These proteins are coded for by genes in chromosomal DNA, bacteriophage DNA or plasmids . Certain bacteria employ mobile genetic elements and horizontal gene transfer . Therefore, strategies to combat certain bacterial infections by targeting these specific virulence factors and mobile genetic elements have been proposed. Bacteria
Bacteria
use quorum sensing to synchronise release of the molecules. These are all proximate causes of morbidity in the host.

METHODS BY WHICH BACTERIA CAUSE DISEASE

* Adhesion Colonization ADHESION. Many bacteria must first bind to host cell surfaces. Many bacterial and host molecules that are involved in the adhesion of bacteria to host cells have been identified. Often, the host cell receptors for bacteria are essential proteins for other functions. Due to presence of mucous lining and of anti-microbial substances around some host cells, it is difficult for certain pathogens to establish direct contact-adhesion. * COLONIZATION. Some virulent bacteria produce special proteins that allow them to colonize parts of the host body. Helicobacter pylori
Helicobacter pylori
is able to survive in the acidic environment of the human stomach by producing the enzyme urease . Colonization of the stomach lining by this bacterium can lead to Gastric ulcer
Gastric ulcer
and cancer . The virulence of various strains of Helicobacter pylori
Helicobacter pylori
tends to correlate with the level of production of urease. Invasion * INVASION. Some virulent bacteria produce proteins that either disrupt host cell membranes or stimulate their own endocytosis or macro-pinocytosis into host cells. These virulence factors allow the bacteria to enter host cells and facilitate entry into the body across epithelial tissue layers at the body surface. * IMMUNE RESPONSE INHIBITORS. Many bacteria produce virulence factors that inhibit the host's immune system defenses. For example, a common bacterial strategy is to produce proteins that bind host antibodies. The polysaccharide capsule of Streptococcus pneumoniae inhibits phagocytosis of the bacterium by host immune cells. * TOXINS. Many virulence factors are proteins made by bacteria that poison host cells and cause tissue damage. For example, there are many food poisoning toxins produced by bacteria that can contaminate human foods. Some of these can remain in "spoiled" food even after cooking and cause illness when the contaminated food is consumed. Some bacterial toxins are chemically altered and inactivated by the heat of cooking.

VIRULENT VIRUSES

Virus virulence factors allow it replicate, modify host defenses, allow it to spread within the host, and are toxic to the host.

They determine whether infection occurs and how severe the resulting viral disease symptoms are. Viruses often require receptor proteins on host cells to which they specifically bind. Typically, these host cell proteins are endocytosed and the bound virus then enters the host cell. Virulent viruses such as HIV
HIV
, which causes AIDS, have mechanisms for evading host defenses. HIV
HIV
infects T-Helper Cells, which leads to a reduction of the adaptive immune response of the host and eventually leads to an immunocompromised state. Death results from opportunistic infections secondary to disruption of the immune system caused by AIDS. Some viral virulence factors confer ability to replicate during the defensive inflammation responses of the host such as during virus-induced fever . Many viruses can exist inside a host for long periods during which little damage is done. Extremely virulent strains can eventually evolve by mutation and natural selection within the virus population inside a host. The term "neurovirulent " is used for viruses such as rabies and herpes simplex which can invade the nervous system and cause disease there.

Extensively studied model organisms of virulent viruses include virus T4 and other T-even bacteriophages which infect Escherichia coli and a number of related bacteria .

The lytic life cycle of virulent bacteriophages is contrasted by the temperate lifecycle of Temperate bacteriophages.

EVOLUTION

Main article: Optimal virulence

According to evolutionary medicine , optimal virulence increases with horizontal transmission (between non-relatives) and decreases with vertical transmission (from parent to child). This is because the fitness of the host is bound to the fitness in vertical transmission but is not so bound in horizontal transmission.

SEE ALSO

* Host-pathogen interface * Membrane vesicle trafficking * Bacterial effector protein * Infectious disease * Optimal virulence * Super-spreader * Verotoxin-producing Escherichia coli * Virulence factor * Antivirulence

REFERENCES

Wikimedia Commons has media related to VIRULENCE .

* ^ Thrall, Peter H.; Burdon, Jeremy J. (2003-03-14). " Evolution of Virulence
Virulence
in a Plant Host-Pathogen Metapopulation". Science. 299 (5613): 1735–1737. ISSN 0036-8075 . PMID 12637745 . doi :10.1126/science.1080070 . * ^ Pirofski LA, Casadevall A (2012). "Q and A: What is a pathogen? A question that begs the point" . BMC Biology. 10: 6. PMC 3269390  . PMID 22293325 . doi :10.1186/1741-7007-10-6 . * ^ MeSH - Medical Subject Headings, Karolinska Institute, 13 April 2010 * ^ A B Compact Oxford English Dictionary virulent * ^ A Latin Dictionary virulentus * ^ Encyclopædia Britannica Online, 25 May 2009. "plant disease development" * ^ Keen, E. C. (December 2012). "Paradigms of pathogenesis: Targeting the mobile genetic elements of disease" . Frontiers in Cellular and Infection Microbiology. 2: 161. PMC 3522046  . PMID 23248780 . doi :10.3389/fcimb.2012.00161 . * ^ Flint, S.Jane; Enquist, Lynn W.; Racaniello, Vincent R.; Skalka, Anna Marie (2009). Principles of Virology. Vol. II Pathogenesis and Control (3rd ed.). Washington, D.C.: ASM. pp. 42–47. ISBN 978-1-55581-480-9 . * ^ Madigan M, Martinko J (editors) (2006). Brock Biology of Microorganisms (11th ed.). Prentice Hall. ISBN 0-13-144329-1 . CS1 maint: Extra text: authors list (link ) * ^ Encyclopædia Britannica Online, 2009. "lytic phage"

* v * t * e

Clinical research and experimental design

OVERVIEW

* Clinical trial
Clinical trial

* Trial protocols * Adaptive clinical trial

* Academic clinical trials * Clinical study design

Controlled study (EBM I to II-1; A to B )

* Randomized controlled trial

* Scientific experiment * Blind experiment * Open-label trial

Observational study (EBM II-2 to II-3; B to C )

* Cross-sectional study vs. Longitudinal study , Ecological study

* Cohort study

* Retrospective * Prospective

* Case-control study
Case-control study
( Nested case-control study ) * Case series * Case study * Case report

Epidemiology / methods

* occurrence : Incidence ( Cumulative incidence )

* Prevalence

* Point * Period

* association : absolute ( Absolute risk reduction , Attributable risk , Attributable risk percent ) * relative ( Relative risk , Odds ratio , Hazard ratio )

* other : Clinical endpoint * Virulence * Infectivity * Mortality rate * Morbidity * Case fatality rate * Specificity and sensitivity * Likelihood-ratios * Pre/post-test probability

TRIAL/TEST TYPES

* In vitro * In vivo * Animal testing
Animal testing
* Animal testing
Animal testing
on non-human primates * First-in-man study * Multicenter trial * Seeding trial * Vaccine trial

ANALYSIS OF CLINICAL TRIALS

* Risk–benefit ratio * Systematic review * Replication * Meta-analysis * Intention-to-treat analysis

INTERPRETATION OF RESULTS

* Selection bias * Survivorship bias * Correlation does not imply causation * Null result

* CATEGORY * GLOSSARY * LIST OF TOPICS

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