Vamsi Mootha
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Vamsi K. Mootha is an
India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...
n-born
American American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, pe ...
physician-scientist and
computational biologist Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has fo ...
. He is an Investigator of the
Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...
, Professor of Systems Biology and Medicine at
Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...
, Investigator in the Department of Molecular Biology at
Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United Stat ...
. He is also an Institute Member of the
Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, Cambridge, Massachusetts, U ...
. Mootha and his research group have made major contributions to mitochondrial biology and genomics. His group characterized the mammalian mitochondrial proteome and has produced a widely utilized resource called MitoCarta. Working with clinical collaborators, his team used the inventory to identify a very large number of mitochondrial disease genes. Mootha and his team used “integrative genomics” to identify all of the molecular components of the mitochondrial calcium uniporter, a key channel of communication between the organelle and the rest of the cell. He and his team used genomics to make the unexpected discovery that in animal models, low oxygen can alleviate mitochondrial disease. As a postdoctoral fellow he developed Gene Set Enrichment Analysis, an algorithm that is widely used in genomics and has been implemented into a popular software tool. He is a 2004 recipient of the Macarthur Foundation "genius award". He received the 2008 Daland Prize from the
American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...
, the 2014 Keilin Medal from the Biochemical Society, and a 2014
Padma Shri Padma Shri (IAST: ''padma śrī''), also spelled Padma Shree, is the fourth-highest Indian honours system, civilian award of the Republic of India, after the Bharat Ratna, the Padma Vibhushan and the Padma Bhushan. Instituted on 2 January 1954, ...
Award from the
Republic of India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...
, the fourth highest civilian award given by the Indian government. He was elected to the United States National Academy of Sciences in 2014 and the National Academy of Medicine in 2021. Mootha graduated from Kelly High School in Beaumont, Texas. As a high school student he won first place in the mathematics category of the
International Science and Engineering Fair The Regeneron International Science and Engineering Fair (ISEF) is an annual science fair in the United States. It is owned and administered by the Society for Science, a 501(c)(3) non-profit organization based in Washington, D.C. Each May, more tha ...
. He received his BS in Mathematical and Computational Science from
Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
and his M.D. from
Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
in the Harvard-MIT Division of Health Sciences and Technology. He completed his internship and residency in internal medicine at
Brigham and Women's Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts Gener ...
in Boston, and then pursued postdoctoral training with
Eric Lander Eric Steven Lander (born February 3, 1957) is an American mathematician and geneticist who served as the 11th director of the Office of Science and Technology Policy and Science Advisor to the President, serving on the presidential Cabinet. Lan ...
at the Whitehead Institute/MIT
Center for Genome Research The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institut ...
.Mootha Laboratory
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References

{{DEFAULTSORT:Mootha, Vamsi Living people Telugu people MacArthur Fellows American people of Telugu descent Systems biologists Stanford University alumni Harvard Medical School alumni American people of Indian descent Harvard Medical School faculty People from Beaumont, Texas Howard Hughes Medical Investigators Scientists from Andhra Pradesh Massachusetts General Hospital faculty Recipients of the Padma Shri in medicine People from Kakinada Members of the United States National Academy of Sciences Year of birth missing (living people) Members of the National Academy of Medicine