Medical uses
Etoposide is used as a form of chemotherapy for cancers such as Kaposi’s sarcoma, Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, nonlymphocytic leukemia, and glioblastoma multiforme. It is often given in combination with other drugs (such as bleomycin in treating testicular cancer). It is also sometimes used in a conditioning regimen prior to a bone marrow transplant, bone marrow or stem cell transplant, blood stem cell transplant.Administration
It is given intravenously (IV) or orally in capsule or tablet form. If the drug is given IV, it must be done slowly over a 30- to 60-minute period because it can lower blood pressure as it is being administered. Blood pressure is checked often during infusing, with the speed of administration adjusted accordingly.Side effects
Common are: * infusion site reactions * hypotension, low blood pressure * alopecia, hair loss * pain and or burning at the IV site * constipation or diarrhea * parageusia, metallic food taste * bone marrow suppression, leading to: ** decreased white blood cell counts (leading to increased susceptibility to infections) ** low red blood cell counts (anemia) ** low platelet counts (leading to easy bruising and bleeding) Less common are: * nausea and vomiting * allergic-type reactions * rash * fever, often occurring shortly after IV administration and not due to infection * mouth ulcer, mouth sores * acute myeloid leukemia (which can be treated with etoposide itself) When given with warfarin, it may cause bleeding.Pharmacology
Mechanism of action
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme, which is an enzyme that aids in relaxing negative or positive supercoils in DNA. Topoisomerase II normally will form a double-stranded break in one DNA double-strand, allow another to pass through, and Ligation (molecular biology), re-ligate the broken strands. Etoposide's binding prevents topoisomerase II from Ligation (molecular biology), re-ligating the broken DNA strands, which causes the DNA breaks made by topoisomerase II to stay broken, and also prevents the topoisomerase II molecule from leaving the site and relieving tension elsewhere. This results in a double-strand break in the DNA that can have various deleterious effects on the cell, and depletion of topoisomerase II available to relieve further tension. Cancer cells rely on this enzyme more than healthy cells, since they divide more rapidly. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.Chemistry
Etoposide is a semisynthetic derivative of podophyllotoxin from the rhizome of the wild mandrake (''Podophyllum peltatum''). More specifically, it is a glycoside of podophyllotoxin with a D-glucose derivative. It is chemically similar to the anti-cancer drug teniposide, being distinguished only by a methyl group where teniposide has a thienyl. Both these compounds have been developed with the aim of creating less toxic derivatives of podophyllotoxin. The substance is a white to yellow-brown, crystalline powder. It is soluble in organic solvents. It is used in form of its salt (chemistry), salt etoposide phosphate.History
Etoposide was first synthesized in 1966 and U.S. Food and Drug Administration approval was granted in 1983. The nickname VP-16 likely comes from a compounding of the last name of one of the chemists who performed early work on the drug (von Wartburg) and podophyllotoxin. Another scientist who was integral in the development of podophyllotoxin-based chemotherapeutics was the medical pharmacologist Hartmann F. Stähelin.References
External links
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