Upstream stimulatory factor 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''USF1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
This gene encodes a member of the
basic helix-loop-helix leucine zipper family and can function as a cellular
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
. The encoded protein can activate transcription through pyrimidine-rich
initiator
An initiator can refer to:
* A person who instigates something.
* Modulated neutron initiator, a neutron source used in some nuclear weapons
** Initiator, an Explosive booster
** Initiator, the first Nuclear chain reaction
* Pyrotechnic initiator, ...
(Inr) elements and
E-box An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues. Its specific DNA sequence, CANNTG (where N can ...
motifs. This gene has been linked to
familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct
isoforms
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. While many perform the same or similar biological roles, some iso ...
have been identified for this gene.
A study of mice suggested reduced USF1 levels increases metabolism in
brown fat.
Interactions
USF1 (human gene) has been shown to
interact
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with
USF2,
FOSL1
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the ''FOSL1'' gene.
Function
The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with ...
and
GTF2I
General transcription factor II-I is a protein that in humans is encoded by the ''GTF2I'' gene.
Function
This gene encodes a multifunctional phosphoprotein, TFII-I, with roles in transcription and signal transduction. Haploinsuffiency (deletio ...
.
References
Further reading
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External links
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{{Transcription factors, g1
Transcription factors