Tybamate (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...

; Solacen, Tybatran, Effisax) is an

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

of the carbamate family. It is a prodrug for

meprobamate Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the be ...

in the same way as the better known drug carisoprodol. It has liver enzyme inducing effects similar to those of

phenobarbital Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the treatment of certain types of ep ...

but much weaker. As the trade name Tybatran (

Robins Robins may refer to: Places United States *Robins, Iowa, a small city * Robins, Ohio, an unincorporated community * Robins Township, Fall River County, South Dakota * Robins Island, of the coast of New York state *Robins Air Force Base, Georgia *R ...

), it was formerly available in capsules of 125, 250, and 350 mg, taken 3 or 4 times a day for a total daily dosage of 750 mg to 2 g. The plasma half-life of the drug is three hours. At high doses in combination with

phenothiazine Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. T ...

s, it could produce convulsions.

References

Anxiolytics Carbamates Prodrugs GABAA receptor positive allosteric modulators {{Anxiolytic-stub