Truth serum
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"Truth serum" is a colloquial name for any of a range of psychoactive drugs used in an effort to obtain information from subjects who are unable or unwilling to provide it otherwise. These include
ethanol Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a ...
,
scopolamine Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is formally used as a medication for treating motion sickness and postoperative nausea and vomi ...
,
3-quinuclidinyl benzilate 3-Quinuclidinyl benzilate (QNB) (IUPAC name 1-azabicyclo .2.2ctan-3-yl hydroxy(diphenyl)acetate; US Army code EA-2277; NATO code BZ; Soviet code Substance 78) is an odorless and bitter-tasting military incapacitating agent.QNB: Incapacitating Age ...
, midazolam,
flunitrazepam Flunitrazepam, also known as Rohypnol among other names, is a benzodiazepine used to treat severe insomnia and assist with anesthesia. As with other hypnotics, flunitrazepam has been advised to be prescribed only for short-term use or by those ...
, sodium thiopental, and amobarbital, among others. Although a variety of such substances have been tested, serious issues have been raised about their use scientifically, ethically and legally. There is currently no drug proven to cause consistent or predictable enhancement of truth-telling. Subjects questioned under the influence of such substances have been found to be suggestible and their memories subject to reconstruction and fabrication. When such drugs have been used in the course of investigating civil and criminal cases, they have not been accepted by Western legal systems and legal experts as genuine investigative tools. In the United States, it has been suggested that their use is a potential violation of the Fifth Amendment of the U.S. Constitution (the right to remain silent). Concerns have also been raised through the
European Court of Human Rights The European Court of Human Rights (ECHR or ECtHR), also known as the Strasbourg Court, is an international court of the Council of Europe which interprets the European Convention on Human Rights. The court hears applications alleging that ...
arguing that use of a truth serum could be considered a violation of a human right to be free from degrading treatment, or could be considered a form of torture. It has been noted to be a violation of the Inter-American Convention to Prevent and Punish Torture. "Truth serum" was abused against psychotic patients as part of old, discredited practices of
psychiatry Psychiatry is the medical specialty devoted to the diagnosis, prevention, and treatment of mental disorders. These include various maladaptations related to mood, behaviour, cognition, and perceptions. See glossary of psychiatry. Initial p ...
and is no longer used. In a therapeutic context, the controlled administration of
intravenous Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutrie ...
hypnotic Hypnotic (from Greek ''Hypnos'', sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia ...
medications is called "
narcosynthesis In the post-World War II era, the technique of narcosynthesis (as it was later called) was developed by psychiatrists as a means of treating patients who suffered from posttraumatic stress disorder. Narcosynthesis—also called sodium amytal inte ...
" or "narcoanalysis". Such application was first documented by Dr.
William Bleckwenn William Jefferson Bleckwenn (July 23, 1895 – January 6, 1965) was an American neurologist, psychiatrist, and military physician, who was instrumental in developing the treatment known as "narcoanalysis" or "narcosynthesis", also known by the la ...
. Reliability and suggestibility of patients are concerns, and the practice of chemically inducing an involuntary mental state is now widely considered to be a form of torture.


Active chemical substances

Sedative A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but ...
s or
hypnotic Hypnotic (from Greek ''Hypnos'', sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia ...
s that alter higher cognitive function include
ethanol Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a ...
,
scopolamine Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is formally used as a medication for treating motion sickness and postoperative nausea and vomi ...
,
3-quinuclidinyl benzilate 3-Quinuclidinyl benzilate (QNB) (IUPAC name 1-azabicyclo .2.2ctan-3-yl hydroxy(diphenyl)acetate; US Army code EA-2277; NATO code BZ; Soviet code Substance 78) is an odorless and bitter-tasting military incapacitating agent.QNB: Incapacitating Age ...
, potent short or intermediate acting hypnotic
benzodiazepines Benzodiazepines (BZD, BDZ, BZs), sometimes called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, ...
such as midazolam,
flunitrazepam Flunitrazepam, also known as Rohypnol among other names, is a benzodiazepine used to treat severe insomnia and assist with anesthesia. As with other hypnotics, flunitrazepam has been advised to be prescribed only for short-term use or by those ...
, and various short and ultra-short acting
barbiturates Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as we ...
, including sodium thiopental (commonly known by the brand name Pentothal) and amobarbital (formerly known as sodium amytal).


Reliability

While there have been many clinical studies of the efficacy of narcoanalysis in interrogation or lie detection, there is dispute whether any of them qualify as a
randomized In common usage, randomness is the apparent or actual lack of pattern or predictability in events. A random sequence of events, symbols or steps often has no order and does not follow an intelligible pattern or combination. Individual ran ...
,
controlled study A scientific control is an experiment or observation designed to minimize the effects of variables other than the independent variable (i.e. confounding variables). This increases the reliability of the results, often through a comparison betwe ...
, that would meet scientific standards for determining effectiveness.There is some controversy to this point; see IJME debate in and A simple search: Indirecy quotation from B.M. Mohan


Use by country


India

India's
Central Bureau of Investigation The Central Bureau of Investigation (CBI) is the premier investigating agency of India. It operates under the jurisdiction of the Ministry of Personnel, Public Grievances and Pensions. Originally set up to investigate bribery and government ...
has used intravenous barbiturates for interrogation, often in high-profile cases. One such case was the interrogation of Ajmal Kasab, the only terrorist captured alive by police in the 2008 attacks in Mumbai, India. Kasab was a PakistaniThe
government of Pakistan The Government of Pakistan ( ur, , translit=hakúmat-e pákistán) abbreviated as GoP, is a federal government established by the Constitution of Pakistan as a constituted governing authority of the four provinces, two autonomous territorie ...
initially denied that Kasab was a Pakistani citizen, but, in January 2009, it confirmed his citizenship.
militant and a member of the
Lashkar-e-Taiba Lashkar-e-Taiba (LeT; ur, ; literally ''Army of the Good'', translated as ''Army of the Righteous'', or ''Army of the Pure'' and alternatively spelled as ''Lashkar-e-Tayyiba'', ''Lashkar-e-Toiba'', ''Lashkar-i-Taiba'', ''Lashkar-i-Tayyeba'') ...
terrorist group. On 3 May 2010, Kasab was found guilty of 80 offences, including murder, waging war against India, possessing explosives, and other charges. On 6 May 2010, the same trial court sentenced him to death on four counts and to a life sentence on five counts. The Central Bureau of Investigation also conducted this test on Krishna, a key witness and suspect in the high-profile 2008 Aarushi-Hemraj Murder Case to seek more information from Krishna and also determine his credibility as a witness with key information, yet not known to the investigating authorities. Per unverified various media sources, Krishna had purported to have deemed Hemraj (the prime suspect) as not guilty of Aarushi's murder, claiming he emraj"treated Aarushi like his own daughter". On May 5, 2010 the Supreme Court Judge Balasubramaniam in the case "Smt. Selvi vs. State of Karnataka" held that narcoanalysis,
polygraph A polygraph, often incorrectly referred to as a lie detector test, is a device or procedure that measures and records several physiological indicators such as blood pressure, pulse, respiration, and skin conductivity while a person is asked ...
and brain mapping tests were to be allowed after consent of accused. The judge stated: "We are of the considered opinion that no individual can be forced and subjected to such techniques involuntarily, and by doing so it amounts to unwarranted intrusion of personal liberty." In Gujarat, Madhya Pradesh High Court permitted narcoanalysis in the investigation of a killing of a tiger that occurred in May 2010. The Jhurjhura Tigress at Bandhavgarh National Park, a mother of three cubs, was found dead as a result of being hit by a vehicle. A Special Task Force requested the narcoanalysis testing of four persons, one of whom refused to consent on grounds of potential post-test complications.


USSR/Russia

In 2004, ''
Novaya Gazeta ''Novaya Gazeta'' ( rus, Новая газета, t=New Gazette, p=ˈnovəjə ɡɐˈzʲetə) is an independent Russian newspaper known for its critical and investigative coverage of Russian political and social affairs. It is published in Mo ...
'', with reference to KGB General Oleg Kalugin, published an article that said that since the end of the 1980s the First and Second Directorates of the KGB had used, in exceptional cases and mostly on foreign citizens, a soluble odourless, colourless and tasteless substance code-named SP-117, an improved successor to similar drugs used by the KGB prior, that was effective in making a subject lose control of oneself 15 minutes after intake.РЫБКИНУ ДАЛИ СП-117?
''
Novaya Gazeta ''Novaya Gazeta'' ( rus, Новая газета, t=New Gazette, p=ˈnovəjə ɡɐˈzʲetə) is an independent Russian newspaper known for its critical and investigative coverage of Russian political and social affairs. It is published in Mo ...
'', 15 February 2004.
Most importantly, a person who would be given, consecutively, two parts of the drug, i.e. both the "dote" and "antidote", would have no recollection of what had occurred in between and feel afterward as though he had suddenly fallen asleep, the preferable way to administer the "dote" being in an alcoholic drink as the latter would serve as a specious explanation of the sudden onset of drowsiness. Other reports state that SP-117 was just a form of concentrated alcohol meant to be added to alcoholic drinks such as champagne. According to the Russian Foreign Intelligence Service (SVR) officer, Alexander Kouzminov, who quit the service in the early 1990s, the officers of SVR′s Directorate S, which runs SVR′s '' illegals'', primarily used the drug to verify fidelity and trustworthiness of their agents who operated overseas, such as Vitaly Yurchenko.Alexander Kouzminov ''Biological Espionage: Special Operations of the Soviet and Russian Foreign Intelligence Services in the West'', Greenhill Books, 2006,

According to
Alexander Litvinenko Alexander Valterovich "Sasha" Litvinenko (30 August 1962 ( at WebCite) or 4 December 1962 – 23 November 2006) was a British-naturalised Russian defector and former officer of the Russian Federal Security Service (FSB) who specialised i ...
, Russian presidential candidate
Ivan Rybkin Ivan Petrovich Rybkin (; born 20 October 1946) is a Russian politician. He was Chairman of Russia's State Duma in 1994–96 and Secretary of the Security Council in 1996–98. He ran for the Russian presidency in 2004, before dropping out after a ...
was drugged with the same substance by FSB agents during his kidnapping in 2004. Alex Goldfarb and Marina Litvinenko. '' Death of a Dissident: The Poisoning of Alexander Litvinenko and the Return of the KGB''. New York: Free Press, 2007. .


United States

Scopolamine Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is formally used as a medication for treating motion sickness and postoperative nausea and vomi ...
was promoted by obstetrician Robert Ernest House as an advance that would prevent false convictions, beginning in 1922. He had noted that women in childbirth who were given scopolamine could answer questions accurately even while in a state of
twilight sleep Twilight sleep (English translation of the German word ) is an amnesic state characterized by insensitivity to pain without loss of consciousness, induced by an injection of morphine and scopolamine, with the purpose of pain management during ch ...
, and were oftentimes "exceedingly candid" in their remarks. House proposed that scopolamine could be used when interrogating suspected criminals. He even arranged to administer scopolamine to prisoners in the Dallas County jail. Both men were believed to be guilty, both denied guilt under scopolamine, and both were eventually acquitted. In 1926, the use of scopolamine was rejected in a court case, by Judge Robert Walker Franklin, who questioned both its scientific origin, and the uncertainty of its effect. The United States
Office of Strategic Services The Office of Strategic Services (OSS) was the intelligence agency of the United States during World War II. The OSS was formed as an agency of the Joint Chiefs of Staff (JCS) to coordinate espionage activities behind enemy lines for all branc ...
(OSS) experimented with the use of
mescaline Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological ...
,
scopolamine Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is formally used as a medication for treating motion sickness and postoperative nausea and vomi ...
, and
marijuana Cannabis, also known as marijuana among other names, is a psychoactive drug from the cannabis plant. Native to Central or South Asia, the cannabis plant has been used as a drug for both recreational and entheogenic purposes and in various t ...
as possible truth drugs during
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...
. They concluded that the effects were not much different from those of
alcohol Alcohol most commonly refers to: * Alcohol (chemistry), an organic compound in which a hydroxyl group is bound to a carbon atom * Alcohol (drug), an intoxicant found in alcoholic drinks Alcohol may also refer to: Chemicals * Ethanol, one of sev ...
: subjects became more talkative but that did not mean they were more truthful. Like
hypnosis Hypnosis is a human condition involving focused attention (the selective attention/selective inattention hypothesis, SASI), reduced peripheral awareness, and an enhanced capacity to respond to suggestion.In 2015, the American Psychologica ...
, there were also issues of suggestibility and interviewer influence. Cases involving scopolamine resulted in a mixture of testimonies both for and against those suspected, at times directly contradicting each other. LSD was also considered as a possible truth serum, but found unreliable. During the 1950s and 1960s, the United States
Central Intelligence Agency The Central Intelligence Agency (CIA ), known informally as the Agency and historically as the Company, is a civilian foreign intelligence service of the federal government of the United States, officially tasked with gathering, processing, ...
(CIA) carried out a number of investigations including
Project MKUltra Project MKUltra (or MK-Ultra) was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA), intended to develop procedures and identify drugs that could be used in interrogations to weak ...
and Project MKDELTA, which involved illegal use of truth drugs including LSD. A CIA report from 1961, released in 1993, concludes: In 1963, the U.S. Supreme Court ruled, in '' Townsend v. Sain'', that confessions produced as a result of ingestion of truth serum were "unconstitutionally coerced" and therefore inadmissible. The viability of forensic evidence produced from truth sera has been addressed in lower courts – judges and expert witnesses have generally agreed that they are not reliable for lie detection. In 1967, Perry Russo was administered sodium pentothal for interrogation by District Attorney Jim Garrison in the investigation of JFK's assassination. More recently, a judge approved the use of narcoanalysis in the
2012 Aurora, Colorado shooting On July 20, 2012, a mass shooting occurred inside a Century 16 movie theater in Aurora, Colorado, United States, during a midnight screening of the film ''The Dark Knight Rises''. Dressed in tactical clothing, James Holmes set off tear gas g ...
trial to evaluate whether
James Eagan Holmes James Eagan Holmes (born December 13, 1987) is an American mass murderer responsible for the 2012 Aurora, Colorado shooting in which he killed 12 people and injured 70 others (62 directly and eight indirectly) at a Century 16 movie theater on ...
's state of mind was valid for an
insanity plea The insanity defense, also known as the mental disorder defense, is an affirmative defense by excuse in a criminal case, arguing that the defendant is not responsible for their actions due to an episodic psychiatric disease at the time of the cri ...
. Judge William Sylvester ruled that prosecutors would be allowed to interrogate Holmes "under the influence of a medical drug designed to loosen him up and get him to talk", such as sodium amytal, if he filed an insanity plea. The hope was that a 'narcoanalytic interview' could confirm whether or not he had been legally insane on 20 July, the date of the shootings. It is not known whether such an examination was carried out. William Shepherd, chair of the criminal justice section of the
American Bar Association The American Bar Association (ABA) is a voluntary bar association of lawyers and law students, which is not specific to any jurisdiction in the United States. Founded in 1878, the ABA's most important stated activities are the setting of aca ...
, stated, with respect to the Holmes case, that use of a 'truth drug' as proposed, "to ascertain the veracity of a defendant's plea of insanity... would provoke intense legal argument relating to Holmes's right to remain silent under the fifth amendment of the US constitution." Discussing possible effectiveness of such an examination, psychiatrist August Piper stated that "amytal's inhibition-lowering effects in no way prompt the subject to offer up true statements or memories." ''Psychology Today'' Scott Linfield noted, as per Piper, that "there's good reason to believe that truth serums merely lower the threshold for reporting virtually all information, both true and false."


See also

* Human experimentation * Microexpression *
Narcotics The term narcotic (, from ancient Greek ναρκῶ ''narkō'', "to make numb") originally referred medically to any psychoactive compound with numbing or paralyzing properties. In the United States, it has since become associated with opiate ...
* Pharmacological torture *
Polygraph A polygraph, often incorrectly referred to as a lie detector test, is a device or procedure that measures and records several physiological indicators such as blood pressure, pulse, respiration, and skin conductivity while a person is asked ...
*
Project MKUltra Project MKUltra (or MK-Ultra) was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA), intended to develop procedures and identify drugs that could be used in interrogations to weak ...
* Project Chatter * Project Bluebird


References


External links

*{{cite techreport , first=George , last=Bimmerle , title="Truth" Drugs in Interrogation , institution=
CIA The Central Intelligence Agency (CIA ), known informally as the Agency and historically as the Company, is a civilian foreign intelligence service of the federal government of the United States, officially tasked with gathering, processing, ...
, journal=Center for the Study of Intelligence , volume=5 , issue=2 , url=https://www.cia.gov/static/a56eb9be08868b6e14c6ff838ae77087/Truth-Drugs-in-Interrogation.pdf
Informal demonstration of thiopental (video)
'' BBC'', 4 October 2013. *https://www.archives.gov/files/research/jfk/releases/docid-32136896.pdf Psychopharmacology Deception Drug culture Lie detection