Tracazolate (ICI-136,753) is an

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

drug which is used in scientific research. It is a pyrazolopyridine

derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...

, most closely related to

pyrazolopyrimidine Pyrazolopyrimidines are a series of isomeric heterocyclic chemical compounds with the molecular formula C6H5N3. They form the central core of a variety of more complex chemical compounds including some pharmaceuticals and pesticides. Pharmaceu ...

drugs such as

zaleplon Zaleplon, sold under the brand names Sonata among others, is a sedative- hypnotic, used to treat insomnia. It is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. It is manufactured by King Pharmaceuticals and Gedeon Richte ...

, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures. Tracazolate has primarily

and anticonvulsant effects, with sedative and

muscle relaxant A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therap ...

effects only appearing at higher doses. It has a unique receptor binding profile involving allosteric modulation of several GABA_A receptor subtypes, being selective for GABA_A receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.

References

{{Phosphodiesterase inhibitors Adenosine receptor antagonists Anticonvulsants Anxiolytics Carboxylate esters Ethyl esters GABAA receptor positive allosteric modulators Pyrazolopyridines Butyl compounds

See also

References