HOME
The Info List - Tomas Lindahl


--- Advertisement ---



Tomas Robert Lindahl FRS[3] FMedSci[5] (born 28 January 1938) is a Swedish-born British scientist specialising in cancer research.[7] In 2015, he was awarded the Nobel Prize
Nobel Prize
in Chemistry[8] jointly with American chemist Paul L. Modrich
Paul L. Modrich
and Turkish chemist Aziz Sancar
Aziz Sancar
for mechanistic studies of DNA repair.[9][10][11]

Contents

1 Education 2 Career and research 3 Awards and honours 4 References

Education[edit] Lindahl was born in Kungsholmen, Stockholm, Sweden
Sweden
to Folke Robert Lindahl and Ethel Hulda Hultberg.[12] He received a PhD degree in 1967,[13] and an MD degree qualification in 1970, from the Karolinska Institutet in Stockholm.[1] Career and research[edit] After obtaining his research doctorate, Lindahl did postdoctoral research at Princeton University
Princeton University
and Rockefeller University.[14] He was professor of medical chemistry at the University of Gothenburg 1978–82. After moving to the United Kingdom
United Kingdom
he joined the Imperial Cancer Research Fund (now Cancer Research UK) as a researcher in 1981.[14] From 1986 to 2005 he was the first Director of Cancer Research UK's Clare Hall Laboratories in Hertfordshire, since 2015 part of the Francis Crick Institute.[15] He continued to research there until 2009. He has contributed to many papers on DNA repair
DNA repair
and the genetics of cancer.[16][17][18][19][20][21][22][23][24] Awards and honours[edit] Lindahl was elected an EMBO Member in 1974[2] and Fellow of the Royal Society (FRS) in 1988,[4] his certificate of election reads:

“ Dr. Tomas Lindahl
Tomas Lindahl
is noted for his contributions to the comprehension of DNA repair
DNA repair
at the molecular level in bacterial and mammalian cells. He was the first to isolate a mammalian DNA ligase
DNA ligase
and to describe a totally unanticipated novel group of DNA glycosylases as mediators of DNA excision repair. He has also discovered a unique class of enzymes in mammalian cells, namely the methyltransferases, which mediate the adaptive response to alkylation of DNA and has shown that the expression of these enzymes is regulated by the ada gene. More recently he has elucidated the molecular defect in Blooms syndrome [sic] to be the lack of DNA ligase
DNA ligase
I. Apart from providing profound insights into the nature of the DNA repair
DNA repair
process his very important contributions promise to facilitate the design of more selective chemotherapeutic drugs for the treatment of cancer. Lindahl has also made a number of significant contributions to understanding at the DNA level the mechanism of transformation of B-lymphocytes by the Epstein-Barr virus. The most notable of these was the first description of the occurrence in lymphoid cells of closed circular duplex viral DNA.[3] ”

Lindahl received the Royal Society's Royal Medal
Royal Medal
in 2007 "making fundamental contributions to our understanding of DNA repair. His achievements stand out for their great originality, breadth and lasting influence."[25] He is a member of the Norwegian Academy of Science and Letters.[26] He was awarded the Copley Medal in 2010. He was elected a founding Fellow of the Academy of Medical Sciences (FMedSci) in 1998. He shared the Nobel Prize in Chemistry
Nobel Prize in Chemistry
in 2015.[9] The Swedish Academy noted that "The Nobel Prize in Chemistry
Nobel Prize in Chemistry
2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar
Aziz Sancar
'for mechanistic studies of DNA repair'."[27] References[edit]

^ a b LINDAHL, Tomas Robert. ukwhoswho.com. Who's Who. 2015 (online Oxford University Press
Oxford University Press
ed.). A & C Black, an imprint of Bloomsbury Publishing plc.  (subscription required) ^ a b " Tomas Lindahl
Tomas Lindahl
EMBO profile". people.embo.org. Heidelberg: European Molecular Biology Organization.  ^ a b c "Lindahl, Tomas Robert: EC/1988/20". London: The Royal Society. Archived from the original on 2014-11-21.  ^ a b Anon (1988). "Dr Tomas Lindahl
Tomas Lindahl
FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 2015-09-22.  One or more of the preceding sentences incorporates text from the royalsociety.org website where:

“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- Royal Society
Royal Society
Terms, conditions and policies at the Wayback Machine
Wayback Machine
(archived September 25, 2015)

^ a b "Dr Tomas Lindahl
Tomas Lindahl
FRS FMedSci". London: Academy of Medical Sciences. Archived from the original on 2015-10-08.  ^ Lindahl, Tomas (2013). "My Journey to DNA Repair". Genomics, Proteomics & Bioinformatics. 11 (1): 2–7. doi:10.1016/j.gpb.2012.12.001. ISSN 1672-0229.  ^ "Emeritus Scientist - Tomas Lindahl". The Crick. Archived from the original on 2015-12-01.  ^ Tomas Lindahl
Tomas Lindahl
- Nobel Prize in Chemistry
Nobel Prize in Chemistry
2015 on Vimeo ^ a b Broad, William J. (2015-10-07). " Nobel Prize
Nobel Prize
in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar
Aziz Sancar
for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved 2015-10-07.  ^ Staff (7 October 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 – DNA repair – providing chemical stability for life" (PDF). Nobel Prize. Retrieved 2015-10-07.  ^ Cressey, Daniel (2015). " DNA repair
DNA repair
sleuths win chemistry Nobel: Tomas Lindahl, Paul Modrich and Aziz Sancar
Aziz Sancar
share 2015 prize". Nature. 526 (7573): 307–8. doi:10.1038/nature.2015.18515. ISSN 1476-4687. PMID 26469021.  ^ Sweden, Indexed Birth Records, 1860–1941 ^ Lindahl, Tomas (1967). On the structure and stability of nucleic acids in solution. Stockholm.  ^ a b " Cancer Research UK
Cancer Research UK
Grants & Research – Tomas Lindahl". Retrieved 2008-11-10.  ^ "4 ways that Tomas Lindahl’s Nobel Prize
Nobel Prize
for Chemistry revolutionised cancer research", by Emma Smith, CRUK Science blog, 7 October 2015 ^ Gerken, T. is; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2008). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. doi:10.1126/science.1151710. PMC 2668859 . PMID 17991826.  ^ Tomas Lindahl's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required) ^ Lindahl, T. (1993). "Instability and decay of the primary structure of DNA". Nature. 362 (6422): 709–15. doi:10.1038/362709a0. PMID 8469282.  ^ Wood, R. D. (2001). "Human DNA Repair Genes". Science. 291 (5507): 1284–9. doi:10.1126/science.1056154. PMID 11181991.  ^ Satoh, M. S.; Lindahl, T. (1992). "Role of poly(ADP-ribose) formation in DNA repair". Nature. 356 (6367): 356. doi:10.1038/356356a0. PMID 1549180.  ^ Trewick, S. C.; Henshaw, T. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature. 419 (6903): 174–8. doi:10.1038/nature00908. PMID 12226667.  ^ Barnes, D. E.; Lindahl, T (2004). "Repair and genetic consequences of endogenous DNA base damage in mammalian cells". Annual Review of Genetics. 38: 445–76. doi:10.1146/annurev.genet.38.072902.092448. PMID 15568983.  ^ Yang, Y. G.; Lindahl, T; Barnes, D. E. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease". Cell. 131 (5): 873–86. doi:10.1016/j.cell.2007.10.017. PMID 18045533.  ^ Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, D. N.; Van Bokhoven, H; Brunner, H. G.; Hamel, B. C.; Corry, P. C.; Cowan, F. M.; Frints, S. G.; Klepper, J; Livingston, J. H.; Lynch, S. A.; Massey, R. F.; Meritet, J. F.; Michaud, J. L.; Ponsot, G; Voit, T; Lebon, P; Bonthron, D. T.; Jackson, A. P.; Barnes, D. E.; Lindahl, T (2006). "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus". Nature Genetics. 38 (8): 917–20. doi:10.1038/ng1845. PMID 16845398.  ^ "Royal recent winners". Retrieved 2008-11-10.  ^ "Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian). Norwegian Academy of Science and Letters. Retrieved 2010-10-07.  ^ "The Nobel Prize in Chemistry
Nobel Prize in Chemistry
2015". nobelprize.org. 

v t e

Copley Medallists (2001–present)

Jacques Miller (2001) John Pople (2002) John Gurdon
John Gurdon
(2003) Harry Kroto
Harry Kroto
(2004) Paul Nurse
Paul Nurse
(2005) Stephen Hawking
Stephen Hawking
(2006) Robert May (2007) Roger Penrose
Roger Penrose
(2008) Martin Evans
Martin Evans
(2009) David Cox / Tomas Lindahl
Tomas Lindahl
(2010) Dan McKenzie (2011) John E. Walker (2012) Andre Geim
Andre Geim
(2013) Alec Jeffreys
Alec Jeffreys
(2014) Peter Higgs
Peter Higgs
(2015) Richard Henderson (2016) Andrew Wiles
Andrew Wiles
(2017)

v t e

Francis Crick Institute

Funded by

Cancer Research UK Imperial College London King's College London Medical Research Council University College London Wellcome Trust

Senior staff

Simon Boulton Doreen Cantrell David Cooksey Julian Downward Jeremy Farrar Steve Gamblin Peter Gruss Adrian Hayday Tim Hunt Malcolm Irving Harpal Kumar Robin Lovell-Badge Tomas Lindahl Paul Nurse Anne O'Garra Keith Peters Geraint Rees John Skehel Jim Smith Richard Treisman Frank Uhlmann Jean-Paul Vincent David Willetts Philip Yea

Incorporating

National Institute for Medical Research London Research Institute

v t e

Laureates of the Nobel Prize
Nobel Prize
in Chemistry

1901–1925

1901 Jacobus van 't Hoff 1902 Emil Fischer 1903 Svante Arrhenius 1904 William Ramsay 1905 Adolf von Baeyer 1906 Henri Moissan 1907 Eduard Buchner 1908 Ernest Rutherford 1909 Wilhelm Ostwald 1910 Otto Wallach 1911 Marie Curie 1912 Victor Grignard
Victor Grignard
/ Paul Sabatier 1913 Alfred Werner 1914 Theodore Richards 1915 Richard Willstätter 1916 1917 1918 Fritz Haber 1919 1920 Walther Nernst 1921 Frederick Soddy 1922 Francis Aston 1923 Fritz Pregl 1924 1925 Richard Zsigmondy

1926–1950

1926 Theodor Svedberg 1927 Heinrich Wieland 1928 Adolf Windaus 1929 Arthur Harden
Arthur Harden
/ Hans von Euler-Chelpin 1930 Hans Fischer 1931 Carl Bosch
Carl Bosch
/ Friedrich Bergius 1932 Irving Langmuir 1933 1934 Harold Urey 1935 Frédéric Joliot-Curie
Frédéric Joliot-Curie
/ Irène Joliot-Curie 1936 Peter Debye 1937 Norman Haworth
Norman Haworth
/ Paul Karrer 1938 Richard Kuhn 1939 Adolf Butenandt
Adolf Butenandt
/ Leopold Ružička 1940 1941 1942 1943 George de Hevesy 1944 Otto Hahn 1945 Artturi Virtanen 1946 James B. Sumner
James B. Sumner
/ John Northrop / Wendell Meredith Stanley 1947 Robert Robinson 1948 Arne Tiselius 1949 William Giauque 1950 Otto Diels
Otto Diels
/ Kurt Alder

1951–1975

1951 Edwin McMillan
Edwin McMillan
/ Glenn T. Seaborg 1952 Archer Martin
Archer Martin
/ Richard Synge 1953 Hermann Staudinger 1954 Linus Pauling 1955 Vincent du Vigneaud 1956 Cyril Hinshelwood / Nikolay Semyonov 1957 Alexander Todd 1958 Frederick Sanger 1959 Jaroslav Heyrovský 1960 Willard Libby 1961 Melvin Calvin 1962 Max Perutz
Max Perutz
/ John Kendrew 1963 Karl Ziegler
Karl Ziegler
/ Giulio Natta 1964 Dorothy Hodgkin 1965 Robert Woodward 1966 Robert S. Mulliken 1967 Manfred Eigen
Manfred Eigen
/ Ronald Norrish / George Porter 1968 Lars Onsager 1969 Derek Barton / Odd Hassel 1970 Luis Federico Leloir 1971 Gerhard Herzberg 1972 Christian B. Anfinsen
Christian B. Anfinsen
/ Stanford Moore / William Stein 1973 Ernst Otto Fischer
Ernst Otto Fischer
/ Geoffrey Wilkinson 1974 Paul Flory 1975 John Cornforth
John Cornforth
/ Vladimir Prelog

1976–2000

1976 William Lipscomb 1977 Ilya Prigogine 1978 Peter D. Mitchell 1979 Herbert C. Brown
Herbert C. Brown
/ Georg Wittig 1980 Paul Berg
Paul Berg
/ Walter Gilbert
Walter Gilbert
/ Frederick Sanger 1981 Kenichi Fukui
Kenichi Fukui
/ Roald Hoffmann 1982 Aaron Klug 1983 Henry Taube 1984 Robert Merrifield 1985 Herbert A. Hauptman
Herbert A. Hauptman
/ Jerome Karle 1986 Dudley R. Herschbach
Dudley R. Herschbach
/ Yuan T. Lee
Yuan T. Lee
/ John Polanyi 1987 Donald J. Cram
Donald J. Cram
/ Jean-Marie Lehn
Jean-Marie Lehn
/ Charles J. Pedersen 1988 Johann Deisenhofer
Johann Deisenhofer
/ Robert Huber
Robert Huber
/ Hartmut Michel 1989 Sidney Altman / Thomas Cech 1990 Elias Corey 1991 Richard R. Ernst 1992 Rudolph A. Marcus 1993 Kary Mullis
Kary Mullis
/ Michael Smith 1994 George Olah 1995 Paul J. Crutzen
Paul J. Crutzen
/ Mario J. Molina
Mario J. Molina
/ Frank Rowland 1996 Robert Curl
Robert Curl
/ Harold Kroto / Richard Smalley 1997 Paul D. Boyer
Paul D. Boyer
/ John E. Walker / Jens Christian Skou 1998 Walter Kohn
Walter Kohn
/ John Pople 1999 Ahmed Zewail 2000 Alan J. Heeger / Alan MacDiarmid / Hideki Shirakawa

2001–present

2001 William Knowles / Ryoji Noyori / K. Barry Sharpless 2002 John B. Fenn / Koichi Tanaka
Koichi Tanaka
/ Kurt Wüthrich 2003 Peter Agre
Peter Agre
/ Roderick MacKinnon 2004 Aaron Ciechanover
Aaron Ciechanover
/ Avram Hershko
Avram Hershko
/ Irwin Rose 2005 Robert H. Grubbs
Robert H. Grubbs
/ Richard R. Schrock
Richard R. Schrock
/ Yves Chauvin 2006 Roger D. Kornberg 2007 Gerhard Ertl 2008 Osamu Shimomura
Osamu Shimomura
/ Martin Chalfie
Martin Chalfie
/ Roger Y. Tsien 2009 Venkatraman Ramakrishnan
Venkatraman Ramakrishnan
/ Thomas A. Steitz
Thomas A. Steitz
/ Ada E. Yonath 2010 Richard F. Heck
Richard F. Heck
/ Akira Suzuki / Ei-ichi Negishi 2011 Dan Shechtman 2012 Robert Lefkowitz
Robert Lefkowitz
/ Brian Kobilka 2013 Martin Karplus
Martin Karplus
/ Michael Levitt
Michael Levitt
/ Arieh Warshel 2014 Eric Betzig
Eric Betzig
/ Stefan Hell
Stefan Hell
/ William E. Moerner 2015 Tomas Lindahl
Tomas Lindahl
/ Paul L. Modrich
Paul L. Modrich
/ Aziz Sancar 2016 Jean-Pierre Sauvage
Jean-Pierre Sauvage
/ Fraser Stoddart
Fraser Stoddart
/ Ben Feringa 2017 Jacques Dubochet
Jacques Dubochet
/ Joachim Frank
Joachim Frank
/ Richard Henderson

v t e

2015 Nobel Prize
Nobel Prize
laureates

Chemistry

Tomas Lindahl
Tomas Lindahl
(Sweden, United Kingdom) Paul L. Modrich
Paul L. Modrich
(United States) Aziz Sancar
Aziz Sancar
(Turkey, United States)

Literature

Svetlana Alexievich
Svetlana Alexievich
(Belarus)

Peace (2015)

Tunisian National Dialogue Quartet
Tunisian National Dialogue Quartet
(Tunisia)

Physics

Takaaki Kajita
Takaaki Kajita
(Japan) Arthur B. McDonald
Arthur B. McDonald
(Canada)

Physiology or Medicine

William C. Campbell (Ireland, United States) Satoshi Ōmura
Satoshi Ōmura
(Japan) Tu Youyou
Tu Youyou
(China)

Economic Sciences

Angus Deaton
Angus Deaton
(United Kingdom, United States)

Nobel Prize
Nobel Prize
recipients 1990 91 92 93 94 95 96 97 98 99 2000 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 17

v t e

Swedish Nobel laureates

Chemistry

1903: Svante Arrhenius 1926: Theodor Svedberg 1929: Hans von Euler-Chelpin 1948: Arne Tiselius 2015: Tomas Lindahl

Literature

1909: Selma Lagerlöf 1916: Verner von Heidenstam 1931: Erik Axel Karlfeldt
Erik Axel Karlfeldt
(posthumously) 1951: Pär Lagerkvist 1966: Nelly Sachs 1974: Eyvind Johnson
Eyvind Johnson
/ Harry Martinson 2011: Tomas Tranströmer

Peace

1908: Klas Pontus Arnoldson 1921: Hjalmar Branting 1930: Nathan Söderblom 1961: Dag Hammarskjöld
Dag Hammarskjöld
(posthumously) 1982: Alva Myrdal

Physics

1912: Gustaf Dalén 1924: Manne Siegbahn 1970: Hannes Alfvén 1981: Kai Siegbahn

Physiology or Medicine

1911: Allvar Gullstrand 1955: Hugo Theorell 1967: Ragnar Granit 1970: Ulf von Euler 1981: Torsten Wiesel 1982: Sune Bergström
Sune Bergström
/ Bengt I. Samuelsson 2000: Arvid Carlsson

Economic Sciences

1974: Gunnar Myrdal 1977: Bertil Ohlin

Authority control

WorldCat Identities VIAF: 18744768 LCCN: n87846878 ISNI: 0000 0000 5957 8887 ORCID: 0000-0003-0174-8152 BNF:

.