Thomas Clayton (1777–1854) was an American lawyer and politician. Thomas Clayton may also refer to: *Thomas Clayton (composer) (1673–1725), English musician and opera composer *Thomas Clayton (physician) (c. 1612–1693), MP for Oxford University *Thomas Clayton (American football) (born 1984), American football running back *Tom Clayton (jockey) (1882–1909), Australian jockey *Tom Clayton (footballer) (born 2000), English footballer *Thomas J. Clayton (1826–1900), President Judge of the Thirty-Second Judicial District of Pennsylvania

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