Tinhosa Grande is an uninhabited islet in São Tomé and Príncipe, located southwest of the island of Príncipe and northeast of the island of São Tomé Island, São Tomé. Together with the smaller islet Tinhosa Pequena, 4 kilometers to its north, it forms the Pedras Tinhosas group. It is 55 metres high, and its area is . Since 2012, it forms a part of the UNESCO's Island of Príncipe Biosphere Reserve. A species of skinks found on the islet, ''Trachylepis adamastor'', was first described in 2015.

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{{STP-islands, Tinhosa Grande Uninhabited islands of São Tomé and Príncipe Príncipe Ramsar sites in São Tomé and Príncipe