Tiaprofenic acid is a
nonsteroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration o ...
(NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially
arthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended in children.
Long-term use of tiaprofenic acid is associated with severe
cystitis, roughly 100 times more commonly than other NSAIDs.
It is contraindicated in patients with cystitis and urinary tract infections. It is sparingly metabolised in the
liver
The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it i ...
to two inactive metabolites. Most of the drug is eliminated unchanged in the
urine
Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra.
Cellul ...
. Renal disease impairs excretion, and it should be used with caution in renal disease.
It was patented in 1969 and approved for medical use in 1981.
It is available in
generic
Generic or generics may refer to:
In business
* Generic term, a common name used for a range or class of similar things not protected by trademark
* Generic brand, a brand for a product that does not have an associated brand or trademark, other ...
formulations. A sustained-release preparation is available. It is an
isomer
In chemistry, isomers are molecules or polyatomic ions with identical molecular formulae – that is, same number of atoms of each element – but distinct arrangements of atoms in space. Isomerism is existence or possibility of isomers.
Is ...
of
Suprofen.
References
External links
* Manufacturer Data Shee
Nonsteroidal anti-inflammatory drugs
Diarylketones
Thiophenes
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