The Info List - Thomas Bartholin

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Thomas Bartholin
Thomas Bartholin
(/bɑːrˈtoʊlɪn, ˈbɑːrtəlɪn/; Latinized: Thomas Bartholinus; 20 October 1616 – 4 December 1680) was a Danish physician, mathematician, and theologian. He is best known for his work in the discovery of the lymphatic system in humans and for his advancements of the theory of refrigeration anesthesia, being the first to describe it scientifically. Thomas Bartholin
Thomas Bartholin
came from a family that has become famous for its pioneering scientists, twelve of whom became professors at the University of Copenhagen. Three generations of the Bartholin family made significant contributions to anatomical science and medicine in the 17th and 18th centuries: Thomas Bartholin's father, Caspar Bartholin the Elder (1585–1629), his brother Rasmus Bartholin (1625–1698), and his son Caspar Bartholin the Younger (1655–1738).[1] Thomas Bartholin's son Thomas Bartholin
Thomas Bartholin
the Younger (1659–1690) became a professor of history at the University of Copenhagen
and was later appointed royal antiquarian and secretary to the Royal Archives.[2]


1 Personal life 2 Contributions to medical research 3 Selected works 4 References 5 External links

Personal life[edit] Thomas Bartholin
Thomas Bartholin
was the second of the six sons of Caspar Bartholin the Elder, a physician born in Malmö, Scania
and his spouse Anne Fincke. Bartholin the Elder published the first collected anatomical work in 1611. This work was later augmented, illustrated and revised by Thomas Bartholin, becoming the standard reference on anatomy; the son notably added updates on Harvey's theory of blood circulation and on the lymphatic system. Bartholin visited the Italian botanist Pietro Castelli
Pietro Castelli
at Messina
in 1644. In 1663 Bartholin bought Hagestedgaard, which burned down in 1670 including his library, with the loss of many manuscripts. King Christian V of Denmark
appointed Bartholin as his physician with a substantial salary and freed the farm from taxation as recompense for the loss. In 1680 Bartholin's health failed, the farm was sold, and he moved back to Copenhagen, where he died. He was buried in Vor Frue Kirke (Church of Our Lady). The Bartholinsgade, a street in Copenhagen, is named for the family. Nearby is the Bartholin Institute (Bartholin Institutet). One of the buildings of the University of Aarhus
University of Aarhus
is named after him. Contributions to medical research[edit] In December 1652, Bartholin published the first full description of the human lymphatic system. Jean Pecquet
Jean Pecquet
had previously noted the lymphatic system in animals in 1651, and Pecquet's discovery of the thoracic duct and its entry into the veins made him the first person to describe the correct route of the lymphatic fluid into the blood.[3] Shortly after the publication of Pecquet's and Bartholin's findings, a similar discovery of the human lymphatic system was published by Olof Rudbeck
Olof Rudbeck
in 1653, although Rudbeck had presented his findings at the court of Queen Christina of Sweden in April–May 1652, before Bartholin, but delayed in writing about it until 1653 (after Bartholin). As a result, an intense priority dispute ensued.[4] Niels Stensen
Niels Stensen
or Steno became his most famous pupil. Thomas' publication De nivis usu medico observationes variae Chapter XXII, contains the first known mention of refrigeration anaesthesia, a technique whose invention Thomas Bartholin
Thomas Bartholin
credits to the Italian Marco Aurelio Severino
Marco Aurelio Severino
of Naples.[5] According to Bartholin, Severino was the first to present the use of freezing mixtures of snow and ice (1646), and Thomas Bartholin
Thomas Bartholin
initially learnt about the technique from him during a visit to Naples. Bartholin–Patau syndrome, first described by Thomas Bartholin, is a congenital syndrome of multiple abnormalities produced by trisomy 13.[6] Caspar Bartholin the Elder, Thomas Bartholin's father; his brother Rasmus Bartholin; and his son Caspar Bartholin the Younger
Caspar Bartholin the Younger
(who first described "Bartholin's glands"), all contributed to the practice of modern medicine through their discoveries of important anatomical structures and phenomena.[1] Bartholin the Elder started his tenure as professor at Copenhagen
University in 1613, and over the next 125 years, the scientific accomplishments of the Bartholins while serving on the medical faculty of the University of Copenhagen
won international acclaim and contributed to the reputation of the institution. Selected works[edit]

Antiquitatum veteris puerperii synopsis, 1676

Historiarum anatomicarum rariorum [...] (Case histories of unusual anatomical and clinical structures, including descriptions and illustrations of anomalies and normal structures)

... centuria I et II at Google Books, Amsterdam, 1654. ... centuria III et IV at Google Books. The Hague: Vlacq, 1657. ... centuria V et VI at Google Books, Copenhagen: P. Haubold, 1661 (with Mantissa anatomica, by Johannes Rodius).

De unicornu. Padua, 1645. De Angina Puerorum Campaniae Siciliaeque Epidemica Exercitationes. Paris, 1646. De lacteis thoracicis in homine brutisque nuperrime observatis historia anatomica at Google Books, Copenhagen: M. Martzan, 1652 (Bartholin's discovery of the thoracic duct). Vasa lymphatica nuper Hafniae in animalibus inventa et hepatis exsequiae. Hafniae (Copenhagen), Petrus Hakius, 1653. Vasa lymphatica in homine nuper inventa. Hafniae (Copenhagen), 1654. Historarium anatomicarum rariorum centuria I-VI. Copenhagen, 1654–1661. Anatomia. The Hague. Ex typographia Adriani Vlacq, 1655. Dispensarium hafniense. Copenhagen, 1658. De nivis usu medico observationes variae. Accessit D. Erasmi Bartholini de figura nivis dissertatio. With a book by Rasmus Bartholin. Copenhagen: Typis Matthiase Godichii, sumptibus Petri Haubold, 1661. (Contains the first known mention of refrigeration anaesthesia) Cista medica hafniensis. Copenhagen, 1662. De pulmonum substantia et motu. Copenhagen, 1663. De insolitis partus humani viis. Copenhagen, 1664. De medicina danorum domestica. Copenhagen, 1666. De flammula cordis epistola. Copenhagen, 1667. Orationes et dissertationes omnino varii argumenti. Copenhagen, 1668. Carmina varii argumenti. Copenhagen, 1669. De medicis poetis dissertatio. Hafinae, apud D. Paulli, 1669. De bibliothecae incendio. Copenhagen, 1670. De morbis biblicis miscellanea medica. Francofurti, D. Paulli, 1672. De cruce Christi hypomnemata IV, Typis Andreae ab Hoogenhuysen, Vesaliae (Wesel), 1673. Acta medica et philosophica. 1673–1680.


^ a b Hill, Robert V. (2007) "A Glimpse of Our Past – The contributions of the Bartholin family to the study and practice of clinical anatomy". Clinical Anatomy, Volume 20, Issue 2 (March 2007), pp. 113 – 115. Retrieved 22 February 2007. ^ Jónsson, Már (2012). Arnas Magnæus Philologus (1663–1730). [Odense]: University Press of Southern Denmark. pp. 48–49.  ^ Detmar, Michael and Mihaela Skobe (2000). "Structure, Function, and Molecular Control of the Skin Lymphatic System". Journal of Investigative Dermatology Symposium Proceedings (2000) 5, 14–19. Retrieved 22 February 2007. ^ Eriksson, G. (2004). Svensk medicinhistorisk tidskrift, 2004;8(1):39-44. In Swedish. English abstract at Olaus Rudbeck as scientist and professor of medicine, U.S. National Library
of Medicine. Retrieved 22 February 2007. ^ De nivis, p. 132, p. 132, at Google Books : " nix affricata induit stuporem. Id me docuit Marcus Aurelius Severinus in Gymnasio Neapolitano ". ^ synd/1024 at Who Named It?

External links[edit]

Wikimedia Commons has media related to Thomas Bartholin.

View digitized titles by Thomas Bartholin
Thomas Bartholin
in Botanicus.org Thomas Bartholin
Thomas Bartholin
in Whonamedit.com Bartholin's (1647) De luce animalium – digital facsimile at the Linda Hall Library

Authority control

WorldCat Identities VIAF: 27864975 LCCN: n83201332 ISNI: 0000 0001 1563 6261 GND: 118652850 SELIBR: 297519 SUDOC: 032970757 BNF: cb12389110c (data) BPN: 00588966 NLA: 35903616 NKC: nlk20000079421 ICCU: ITICCUSBLV78209 BNE: XX848