Thiopropazate (Artalan, Dartal, Dartalan, Dartan) is a

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics ma ...

of the

phenothiazine Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. T ...

class. It is a prodrug to

perphenazine Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been in clinical use for decades. Perphenazine is roughly ten times as poten ...

. Thiopropazate is manufactured by Searle (US, UK) & Boehringer Mannheim (Germany) Thiopropazate is sold by Chembase, AAA Chemistry, ZINC, AKos Consulting & Solutions, Boc Sciences, ChemFrog, and ChemMol

Synthesis

The alkylation of 2-chloro-10-(3-chloropropyl)phenothiazine 765-59-5(1) with

Piperazine Piperazine () is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste. The piperazines are a broad ...

(2) gives N-Desmethylprochlorperazine 0323-85-1(3). Further alkylation with 2-Bromoethyl acetate 27-68-4(4) gives ''Thiopropazate'' (5).

References

Acetate esters Chloroarenes Phenothiazines Piperazines Typical antipsychotics {{nervous-system-drug-stub

Synthesis

See also

References