Thiamine-triphosphatase is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
involved in
thiamine metabolism. It
catalyzes the
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:
thiamine triphosphate
Thiamine triphosphate (ThTP) is a biomolecule found in most organisms including bacteria, fungi, plants and animals. Chemically, it is the triphosphate derivative of the vitamin thiamine.
Function
It has been proposed that ThTP has a specific r ...
+ H
2O
thiamine diphosphate
Thiamine pyrophosphate (TPP or ThPP), or thiamine diphosphate (ThDP), or cocarboxylase is a thiamine (vitamin B1) derivative which is produced by the enzyme thiamine diphosphokinase. Thiamine pyrophosphate is a cofactor that is present in all liv ...
+
phosphate
In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid .
The phosphate or orthophosphate ion is derived from phosph ...
This enzyme belongs to the family of
acid anhydride hydrolases, specifically those acting on phosphorus-containing anhydrides. Its
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
is thiamine triphosphate phosphohydrolase.
Structural studies
As of late 2007, only one
structure has been solved for this class of enzymes, with the
PDB accession code .
See also
*
Thiamine-diphosphate kinase
In enzymology, a thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
:thiamine diphosphate + ATP \rightleftharpoons thiamine triphosphate + ADP
Thus, the two substrates of this enzyme a ...
References
*
EC 3.6.1
Enzymes of known structure
{{3.6-enzyme-stub