Teniloxazine (Lucelan, Metatone), also known as sufoxazine and sulfoxazine, is a
drug which is marketed in
Japan.
Though initially investigated as a
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...
and
nootropic
Nootropics ( , or ) (colloquial: smart drugs and cognitive enhancers, similar to adaptogens) are a wide range of natural or synthetic dietary supplement, supplements or drugs and other substances that are claimed to improve cognitive function ...
agent for the treatment of
cerebrovascular insufficiency in the 1980s,
it was ultimately developed and approved as an
antidepressant instead.
It acts as a
potent norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epin ...
, with fair
selectivity over the
serotonin and
dopamine transporters, and also behaves as an
antagonist of the
5-HT2A receptor.
See also
*
Bifemelane
*
Indeloxazine
Indeloxazine (INN) (Elen, Noin) is an antidepressant and cerebral activator that was marketed in Japan and South Korea by Yamanouchi Pharmaceutical Co., Ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, ...
*
Viloxazine
Viloxazine, sold under the brand name Qelbree and formerly as Vivalan among others, is a noradrenergic medication which is used in the treatment of attention deficit hyperactivity disorder (ADHD) in children and adults. It was marketed for almos ...
References
{{Serotonin receptor modulators
Antidepressants
Morpholines
Thiophenes
Phenol ethers