Tenidap was a COX/

5-LOX Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ''ALOX5'' gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase fa ...

inhibitor and

cytokine Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrin ...

-modulating anti-inflammatory drug candidate that was under development by Pfizer as a promising potential treatment for

rheumatoid arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involv ...

, but Pfizer halted development after marketing approval was rejected by the FDA in 1996Pfizer. Sept 27, 199
Press release: Pfizer To Halt Plans For Commercialization Of Tenidap For Rheumatoid Arthritis
due to liver and kidney toxicity, which was attributed to metabolites of the drug with a

thiophene Thiophene is a heterocyclic compound with the formula C4H4S. Consisting of a planar five-membered ring, it is aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene-like odor. In most of its reacti ...

moiety that caused oxidative damage.

References

Indoles Thiophenes Ureas Nonsteroidal anti-inflammatory drugs Chloroarenes Aromatic ketones Phenols Carboxamides Abandoned drugs Drugs developed by Pfizer {{musculoskeletal-drug-stub