UCI most commonly refers to:
* University of California, Irvine, a public university in Irvine, California, United States
* Union Cycliste Internationale, the world governing body for the sport of cycling
UCI may also refer to:
* Uganda Cancer Institute, a cancer treatment and research institution in Kampala, Uganda
* ''Unified Configuration Interface'', a set of scripts to unify and simplify the configuration the OpenWrt operating system
* Union Correctional Institution, Florida, United States
* Unione Cinematografica Italiana, an Italian film company of the silent era
* Unit Compliance Inspection, a United States Air Force inspection
* UCI Cinemas (United Cinemas International), cinema company in Brazil, Germany, Italy and Portugal
* Universal Chess Interface, a communications protocol for chess game software
* Univision Communications Inc., the former name of the American subsidiary of media company TelevisaUnivision
* Unlawful command influence, a term in American military law
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