Zoonotic viral diseases
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A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium, virus, parasite or
prion Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It ...
) that has jumped from a non-human (usually a vertebrate) to a human. Typically, the first infected human transmits the infectious agent to at least one other human, who, in turn, infects others. Major modern diseases such as
Ebola virus disease Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after becom ...
and salmonellosis are zoonoses. HIV was a zoonotic disease transmitted to humans in the early part of the 20th century, though it has now evolved into a separate human-only disease. Most strains of
influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms ...
that infect humans are human diseases, although many strains of
bird flu "Bird Flu" is an urumee melam-dance song by recording artist M.I.A. on her second studio album '' Kala'' (2007). It was released as a digital download in 2006 through XL Recordings under exclusive license to Interscope Records in the US. Cr ...
and swine flu are zoonoses; these viruses occasionally recombine with human strains of the flu and can cause
pandemic A pandemic () is an epidemic of an infectious disease that has spread across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. A widespread endemic (epidemiology), endemic disease wi ...
s such as the
1918 Spanish flu The 1918–1920 influenza pandemic, commonly known by the misnomer Spanish flu or as the Great Influenza epidemic, was an exceptionally deadly global influenza pandemic caused by the H1N1 influenza A virus. The earliest documented case was ...
or the
2009 swine flu The 2009 swine flu pandemic, caused by the influenza A virus subtype H1N1, H1N1 influenza virus and declared by the World Health Organization (WHO) from June 2009 to August 2010, is the third recent flu pandemic involving the H1N1 virus (the f ...
. '' Taenia solium'' infection is one of the neglected tropical diseases with public health and veterinary concern in endemic regions. Zoonoses can be caused by a range of disease pathogens such as emergent viruses, bacteria, fungi and parasites; of 1,415 pathogens known to infect humans, 61% were zoonotic. Most human diseases originated in non-humans; however, only diseases that routinely involve non-human to human transmission, such as rabies, are considered direct zoonoses. Zoonoses have different modes of transmission. In direct zoonosis the disease is directly transmitted from non-humans to humans through media such as air (
influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms ...
) or through bites and saliva ( rabies). In contrast, transmission can also occur via an intermediate species (referred to as a vector), which carry the disease pathogen without getting sick. When humans infect non-humans, it is called reverse zoonosis or anthroponosis. The term is from Greek: ζῷον ''zoon'' "animal" and νόσος ''nosos'' "sickness". Host genetics plays an important role in determining which non-human viruses will be able to make copies of themselves in the human body. Dangerous non-human viruses are those that require few mutations to begin replicating themselves in human cells. These viruses are dangerous since the required combinations of mutations might randomly arise in the natural reservoir.


Causes

The emergence of zoonotic diseases originated with the domestication of animals. Zoonotic transmission can occur in any context in which there is contact with or consumption of animals, animal products, or animal derivatives. This can occur in a companionistic (pets), economic (farming, trade, butchering, etc.), predatory (hunting, butchering or consuming wild game) or research context. Recently, there has been a rise in frequency of appearance of new zoonotic diseases. "Approximately 1.67 million undescribed viruses are thought to exist in
mammal Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or ...
s and birds, up to half of which are estimated to have the potential to spill over into humans," says a study led by researchers at the University of California, Davis. According to a report from the United Nations Environment Programme and
International Livestock Research Institute The International Livestock Research Institute or ILRI is an international agricultural research institute within the CGIAR – formerly the Consultative Group for International Agricultural Research. It was established in 1994 by merger of t ...
large part of the causes are environmental like climate change, unsustainable agriculture, exploitation of wildlife, land use change. Others are linked to changes in human society like more mobility. The organizations propose a set of measures to stop the rise.


Contamination of food or water supply

The most significant zoonotic pathogens causing foodborne diseases are ''Escherichia coli'' O157:H7, ''
Campylobacter ''Campylobacter'' (meaning "curved bacteria") is a genus of Gram-negative bacteria. ''Campylobacter'' typically appear comma- or s-shaped, and are motile. Some ''Campylobacter'' species can infect humans, sometimes causing campylobacteriosis, a d ...
'', ''
Caliciviridae The ''Caliciviridae'' are a family of "small round structured" viruses, members of Class IV of the Baltimore scheme. Caliciviridae bear resemblance to enlarged picornavirus and was formerly a separate genus within the picornaviridae. They are p ...
'', and ''
Salmonella ''Salmonella'' is a genus of rod-shaped (bacillus) Gram-negative bacteria of the family Enterobacteriaceae. The two species of ''Salmonella'' are ''Salmonella enterica'' and ''Salmonella bongori''. ''S. enterica'' is the type species and is fur ...
''. In 2006 a conference held in Berlin focused on the issue of zoonotic pathogen effects on
food safety Food safety (or food hygiene) is used as a scientific method/discipline describing handling, preparation, and storage of food in ways that prevent food-borne illness. The occurrence of two or more cases of a similar illness resulting from t ...
, urging government intervention and public vigilance against the risks of catching
food-borne diseases Foodborne illness (also foodborne disease and food poisoning) is any illness resulting from the spoilage of contaminated food by pathogenic bacteria, viruses, or parasites that contaminate food, as well as prions (the agents of mad cow disease) ...
from farm-to-table dining. Many food-borne outbreaks can be linked to zoonotic pathogens. Many different types of food that have an animal origin can become contaminated. Some common food items linked to zoonotic contaminations include eggs, seafood, meat, dairy, and even some vegetables. Outbreaks involving contaminated food should be handled in preparedness plans to prevent widespread outbreaks and to efficiently and effectively contain outbreaks.


Farming, ranching and animal husbandry

Contact with farm animals can lead to disease in farmers or others that come into contact with infected farm animals. Glanders primarily affects those who work closely with horses and donkeys. Close contact with cattle can lead to
cutaneous anthrax Anthrax is an infection caused by the bacterium ''Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The sk ...
infection, whereas
inhalation anthrax Anthrax is an infection caused by the bacterium '' Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The s ...
infection is more common for workers in
slaughterhouse A slaughterhouse, also called abattoir (), is a facility where animals are slaughtered to provide food. Slaughterhouses supply meat, which then becomes the responsibility of a packaging facility. Slaughterhouses that produce meat that is no ...
s,
tanneries Tanning may refer to: *Tanning (leather), treating animal skins to produce leather *Sun tanning, using the sun to darken pale skin **Indoor tanning, the use of artificial light in place of the sun **Sunless tanning, application of a stain or dye t ...
and
wool mill Textile Manufacturing or Textile Engineering is a major industry. It is largely based on the conversion of fibre into yarn, then yarn into fabric. These are then dyed or printed, fabricated into cloth which is then converted into useful goods s ...
s. Close contact with sheep who have recently given birth can lead to infection with the bacterium '' Chlamydia psittaci,'' causing chlamydiosis (and
enzootic abortion ''Chlamydia abortus'' is a species in Chlamydiota that causes abortion and fetal death in mammals, including humans. ''Chlamydia abortus'' was renamed in 1999 as ''Chlamydophila psittaci'' along with all Chlamydiota except ''Chlamydia trachomat ...
in pregnant women), as well as increase the risk of Q fever, toxoplasmosis, and listeriosis, in the pregnant or otherwise immunocompromised. Echinococcosis is caused by a tapeworm, which can spread from infected sheep by food or water contaminated by feces or wool.
Bird flu "Bird Flu" is an urumee melam-dance song by recording artist M.I.A. on her second studio album '' Kala'' (2007). It was released as a digital download in 2006 through XL Recordings under exclusive license to Interscope Records in the US. Cr ...
is common in chickens and, while rare in humans, the main public health worry is that a strain of bird flu will recombine with a human flu virus and cause a pandemic like the
1918 Spanish flu The 1918–1920 influenza pandemic, commonly known by the misnomer Spanish flu or as the Great Influenza epidemic, was an exceptionally deadly global influenza pandemic caused by the H1N1 influenza A virus. The earliest documented case was ...
. In 2017,
free-range Free range denotes a method of farming husbandry where the animals, for at least part of the day, can roam freely outdoors, rather than being confined in an enclosure for 24 hours each day. On many farms, the outdoors ranging area is fenced, ...
chickens in the UK were temporarily ordered to remain inside due to the threat of bird flu. Cattle are an important reservoir of cryptosporidiosis, which mainly affects the immunocompromised. Reports have shown
mink Mink are dark-colored, semiaquatic, carnivorous mammals of the genera ''Neogale'' and '' Mustela'' and part of the family Mustelidae, which also includes weasels, otters, and ferrets. There are two extant species referred to as "mink": the A ...
can also become infected. In Western countries, Hepatitis E burden is largely dependent on exposure to animal products, and pork is a significant source of infection, in this respect. Veterinarians are exposed to unique occupational hazards when it comes to zoonotic disease. In the US, studies have highlighted an increased risk of injuries and lack of veterinary awareness of these hazards. Research has proved the importance for continued clinical veterinarian education on occupational risks associated with musculoskeletal injuries, animal bites, needle-sticks, and cuts. A July 2020 report by the United Nations Environment Programme stated that the increase in zoonotic pandemics is directly attributable to anthropogenic destruction of nature and the increased global demand for meat, and that the industrial farming of pigs and chickens in particular will be a primary risk factor for the spillover of zoonotic diseases in the future.


Wildlife trade or animal attacks

The wildlife trade may increase spillover risk because it directly increases the number of interactions across animal species, sometimes in small spaces. The origin of the ongoing COVID-19 pandemic is traced to the
wet markets in China In China, wet markets are traditional markets that sell fresh meat, produce, and other perishable goods. They are the most prevalent food outlet in urban regions of China but have faced increasing competition from supermarkets. Since the 1990s, w ...
. * Rabies


Insect vectors

*
African sleeping sickness African trypanosomiasis, also known as African sleeping sickness or simply sleeping sickness, is an insect-borne parasitic infection of humans and other animals. It is caused by the species '' Trypanosoma brucei''. Humans are infected by two ty ...
* Dirofilariasis * Eastern equine encephalitis * Japanese encephalitis * Saint Louis encephalitis * Scrub typhus * Tularemia * Venezuelan equine encephalitis * West Nile fever * Western equine encephalitis * Zika fever


Pets

Pets can transmit a number of diseases. Dogs and cats are routinely vaccinated against rabies. Pets can also transmit ringworm and ''
Giardia ''Giardia'' ( or ) is a genus of anaerobic flagellated protozoan parasites of the phylum Metamonada that colonise and reproduce in the small intestines of several vertebrates, causing the disease giardiasis. Their life cycle alternates between ...
'', which are endemic in both animal and human populations. Toxoplasmosis is a common infection of cats; in humans it is a mild disease although it can be dangerous to pregnant women. Dirofilariasis is caused by '' Dirofilaria immitis'' through mosquitoes infected by mammals like dogs and cats.
Cat-scratch disease Cat-scratch disease (CSD) or felinosis is an infectious disease that most often results from a scratch or bite of a cat. Symptoms typically include a non-painful bump or blister at the site of injury and painful and swollen lymph nodes. People m ...
is caused by '' Bartonella henselae'' and '' Bartonella quintana'', which are transmitted by fleas that are endemic to cats.
Toxocariasis Toxocariasis is an illness of humans caused by the dog roundworm (''Toxocara canis'') and, less frequently, the cat roundworm (''Toxocara cati'').https://academic.oup.com/ajcp/article/142/suppl_1/A104/1771175 Eosinophilic Pseudoleukemia Due to To ...
is the infection of humans by any of species of roundworm, including species specific to dogs ('' Toxocara canis)'' or cats (''
Toxocara cati ''Toxocara cati'', also known as the feline roundworm, is a parasite of cats and other felids. It is one of the most common nematodes of cats, infecting both wild and domestic felids worldwide. Adult worms are localised in the gut of the host. I ...
''). Cryptosporidiosis can be spread to humans from pet lizards, such as the leopard gecko. ''
Encephalitozoon cuniculi ''Encephalitozoon cuniculi'' (''E. cuniculi'') is a mammalian microsporidial pathogen with world-wide distribution. An important cause of neurologic and renal disease in rabbits, ''E. cuniculi'' can also cause disease in immunocompromised people ...
'' is a microsporidial parasite carried by many mammals, including rabbits, and is an important opportunistic pathogen in people immunocompromised by HIV/AIDS, organ transplantation, or CD4+ T-lymphocyte deficiency. Pets may also serve as a reservoir of viral disease and contribute to the chronic presence of certain viral diseases in the human population. For instance, approximately 20% of domestic dogs, cats and horses carry anti-Hepatitis E virus
antibodies An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
and thus these animals probably contribute to human Hepatitis E burden as well. For non-vulnerable populations (people who are not immunocompromised) the associated disease burden is, however, small.


Exhibition

Outbreaks of zoonoses have been traced to human interaction with, and exposure to, other animals at
fair A fair (archaic: faire or fayre) is a gathering of people for a variety of entertainment or commercial activities. Fairs are typically temporary with scheduled times lasting from an afternoon to several weeks. Types Variations of fairs incl ...
s, live animal markets, petting zoos, and other settings. In 2005, the Centers for Disease Control and Prevention (CDC) issued an updated list of recommendations for preventing zoonosis transmission in public settings. The recommendations, developed in conjunction with the National Association of State Public Health Veterinarians, include educational responsibilities of venue operators, limiting public animal contact, and animal care and management.


Hunting and bushmeat

* HIV * SARS


Deforestation, biodiversity loss and environmental degradation

Kate Jones, Chair of Ecology and Biodiversity at University College London, says zoonotic diseases are increasingly linked to environmental change and human behaviour. The disruption of pristine forests driven by logging, mining, road building through remote places, rapid urbanisation and population growth is bringing people into closer contact with animal species they may never have been near before. The resulting transmission of disease from wildlife to humans, she says, is now "a hidden cost of human economic development". In a guest article, published by IPBES, President of the EcoHealth Alliance and zoologist
Peter Daszak Peter Daszak is a British zoologist, consultant and public expert on disease ecology, in particular on zoonosis. He is the president of EcoHealth Alliance, a nonprofit non-governmental organization that supports various programs on global healt ...
, along with three co-chairs of the 2019 '' Global Assessment Report on Biodiversity and Ecosystem Services'', Josef Settele,
Sandra Díaz Sandra Díaz may refer to: *Sandra Díaz (actress) (born c. 1991), Venezuelan actress and model *Sandra Díaz (ecologist) (born 1961), Argentine ecologist *Sandra Diaz-Twine Sandra Diaz-Twine (born July 30, 1974) is an American television perso ...
, and Eduardo Brondizio, wrote that "rampant deforestation, uncontrolled expansion of agriculture, intensive farming, mining and infrastructure development, as well as the exploitation of wild species have created a 'perfect storm' for the spillover of diseases from wildlife to people." Joshua Moon, Clare Wenham and Sophie Harman said that there is evidence that decreased biodiversity has an effect on the diversity of hosts and frequency of human-animal interactions with potential for pathogenic spillover. An April 2020 study, published in the ''
Proceedings of the Royal Society ''Proceedings of the Royal Society'' is the main research journal of the Royal Society. The journal began in 1831 and was split into two series in 1905: * Series A: for papers in physical sciences and mathematics. * Series B: for papers in life s ...
'' Part B journal, found that increased virus spillover events from animals to humans can be linked to biodiversity loss and
environmental degradation Environmental degradation is the deterioration of the environment (biophysical), environment through depletion of resources such as quality of air, water and soil; the destruction of ecosystems; habitat destruction; the extinction of wildlife; an ...
, as humans further encroach on wildlands to engage in agriculture, hunting and resource extraction they become exposed to pathogens which normally would remain in these areas. Such spillover events have been tripling every decade since 1980. An August 2020 study, published in '' Nature'', concludes that the
anthropogenic Anthropogenic ("human" + "generating") is an adjective that may refer to: * Anthropogeny, the study of the origins of humanity Counterintuitively, anthropogenic may also refer to things that have been generated by humans, as follows: * Human im ...
destruction of ecosystems for the purpose of expanding agriculture and human settlements reduces biodiversity and allows for smaller animals such as bats and rats, who are more adaptable to human pressures and also carry the most zoonotic diseases, to proliferate. This in turn can result in more pandemics. In October 2020, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services published its report on the 'era of pandemics' by 22 experts in a variety of fields, and concluded that anthropogenic destruction of biodiversity is paving the way to the pandemic era, and could result in as many as 850,000 viruses being transmitted from animals – in particular birds and mammals – to humans. The increased pressure on ecosystems is being driven by the "exponential rise" in consumption and trade of commodities such as meat, palm oil, and metals, largely facilitated by developed nations, and by a growing human population. According to Peter Daszak, the chair of the group who produced the report, "there is no great mystery about the cause of the Covid-19 pandemic, or of any modern pandemic. The same human activities that drive
climate change and biodiversity loss Climate change has adversely affected both terrestrial and marine ecosystems, and is expected to further affect many ecosystems, including tundra, mangroves, coral reefs, caves etc. Increasing global temperature, more frequent occurrence of ext ...
also drive pandemic risk through their impacts on our environment."


Climate change

According to a report from the United Nations Environment Programme and
International Livestock Research Institute The International Livestock Research Institute or ILRI is an international agricultural research institute within the CGIAR – formerly the Consultative Group for International Agricultural Research. It was established in 1994 by merger of t ...
, entitled "Preventing the next pandemic – Zoonotic diseases and how to break the chain of transmission," climate change is one of the 7 human-related causes of the increase in the number of zoonotic diseases. The University of Sydney issued a study, in March 2021, that examines factors increasing the likelihood of epidemics and pandemics like the COVID-19 pandemic. The researchers found that "pressure on ecosystems, climate change and economic development are key factors" in doing so. More zoonotic diseases were found in
high-income countries A high-income economy is defined by the World Bank as a nation with a gross national income per capita of US$12,696 or more in 2020, calculated using the Atlas method. While the term "high-income" is often used interchangeably with "First World" a ...
. In 2022, a big study dedicated to the link between climate change and Zoonosis was published. The study found a strong link between climate change and the epidemic emergence in the last 15 years, as it caused a massive migration of species to new areas, and consequently contact between species which do not normally come in contact with one another. Even in a scenario with weak climatic changes, there will be 15,000 spillover of viruses to new hosts in the next decades. The areas with the most possibilities for spillover are the mountainous tropical regions of Africa and southeast Asia. Southeast Asia is especially vulnerable as it has a large number of bat species that generally do not mix, but could easily if climate change forced them to begin migrating. A 2021 study found possible links between climate change and transmission of COVID-19 through bats. The authors suggest that climate-driven changes in the distribution and robustness of bat species harboring coronaviruses may have occurred in eastern Asian hotspots (southern China, Myanmar and Laos), constituting a driver behind the evolution and spread of the virus.


Secondary transmission

* Ebola and Marburg are examples of
viral hemorrhagic disease Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection. VHFs may be caused by five distinct families of RNA viruses: the families ''Filoviridae'', ''Flavi ...
.


History

During most of human prehistory groups of hunter-gatherers were probably very small. Such groups probably made contact with other such bands only rarely. Such isolation would have caused epidemic diseases to be restricted to any given local population, because propagation and expansion of epidemics depend on frequent contact with other individuals who have not yet developed an adequate immune response. To persist in such a population, a pathogen either had to be a chronic infection, staying present and potentially infectious in the infected host for long periods, or it had to have other additional species as reservoir where it can maintain itself until further susceptible hosts are contacted and infected. In fact, for many "human" diseases, the human is actually better viewed as an accidental or incidental victim and a
dead-end host In biology and medicine, a host is a larger organism that harbours a smaller organism; whether a parasitic, a mutualistic, or a commensalist ''guest'' (symbiont). The guest is typically provided with nourishment and shelter. Examples include a ...
. Examples include rabies,
anthrax Anthrax is an infection caused by the bacterium ''Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The sk ...
, tularemia and West Nile virus. Thus, much of human exposure to infectious disease has been zoonotic. Many diseases, even epidemic ones, have zoonotic origin and
measles Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...
, smallpox,
influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms ...
, HIV, and diphtheria are particular examples. Various forms of the
common cold The common cold or the cold is a viral infectious disease of the upper respiratory tract that primarily affects the respiratory mucosa of the nose, throat, sinuses, and larynx. Signs and symptoms may appear fewer than two days after exposu ...
and tuberculosis also are adaptations of strains originating in other species. Some experts have suggested that all human viral infections were originally zoonotic. Zoonoses are of interest because they are often previously unrecognized diseases or have increased virulence in populations lacking immunity. The West Nile virus first appeared in the United States in 1999, in the New York City area.
Bubonic plague Bubonic plague is one of three types of plague caused by the plague bacterium (''Yersinia pestis''). One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well a ...
is a zoonotic disease, as are salmonellosis, Rocky Mountain spotted fever, and Lyme disease. A major factor contributing to the appearance of new zoonotic pathogens in human populations is increased contact between humans and wildlife. This can be caused either by encroachment of human activity into wilderness areas or by movement of wild animals into areas of human activity. An example of this is the outbreak of Nipah virus in peninsular Malaysia, in 1999, when intensive pig farming began within the habitat of infected fruit bats. The unidentified infection of these pigs amplified the force of infection, transmitting the virus to farmers, and eventually causing 105 human deaths. Similarly, in recent times avian influenza and West Nile virus have spilled over into human populations probably due to interactions between the carrier host and domestic animals. Highly mobile animals, such as bats and birds, may present a greater risk of zoonotic transmission than other animals due to the ease with which they can move into areas of human habitation. Because they depend on the human host for part of their life-cycle, diseases such as African
schistosomiasis Schistosomiasis, also known as snail fever, bilharzia, and Katayama fever, is a disease caused by parasitic flatworms called schistosomes. The urinary tract or the intestines may be infected. Symptoms include abdominal pain, diarrhea, bloody s ...
, river blindness, and
elephantiasis Elephantiasis is the enlargement and hardening of limbs or body parts due to tissue swelling. It is characterised by edema, hypertrophy, and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels. It may affect the genit ...
are ''not'' defined as zoonotic, even though they may depend on transmission by insects or other vectors.


Use in vaccines

The first vaccine against smallpox by Edward Jenner in 1800 was by infection of a zoonotic bovine virus which caused a disease called cowpox. Jenner had noticed that milkmaids were resistant to smallpox. Milkmaids contracted a milder version of the disease from infected cows that conferred cross immunity to the human disease. Jenner abstracted an infectious preparation of 'cowpox' and subsequently used it to inoculate persons against smallpox. As a result, smallpox has been eradicated globally, and mass vaccination against this disease ceased in 1981. There are a variety of vaccine varieties, including traditional inactivated pathogen vaccines,
Subunit vaccine A subunit vaccine is a vaccine that contains purified parts of the pathogen that are antigenic, or necessary to elicit a protective immune response. A "subunit" vaccine doesn't contain the whole pathogen, unlike live attenuated or inactivated va ...
s, live attenuated vaccines. There are also new vaccine technologies such as viral vector vaccines and DNA/RNA Vaccines, which includes the SARS-CoV-2 Coronavirus vaccines.


Lists of diseases


See also

* * * * * * * * * *


References


Bibliography

* . * * * * H. Krauss, A. Weber, M. Appel, B. Enders, A. v. Graevenitz, H. D. Isenberg, H. G. Schiefer, W. Slenczka, H. Zahner: Zoonoses. Infectious Diseases Transmissible from Animals to Humans. 3rd Edition, 456 pages. ASM Press. American Society for Microbiology, Washington, D.C., 2003. . * *


External links


AVMA Collections: Zoonosis Updates

WHO tropical diseases and zoonoses

Detection and Forensic Analysis of Wildlife and Zoonotic Disease

Publications in Zoonotics and Wildlife Disease

A message from nature: coronavirus
United Nations Environment Programme {{Authority control Animal diseases Disease ecology Infectious diseases