Tedatioxetine (developmental code name Lu AA24530) is an
experimental
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a ...
antidepressant that was discovered by scientists at
Lundbeck
H. Lundbeck A/S (commonly known simply as Lundbeck) is a Danish international pharmaceutical company engaged in the research, development, manufacturing, marketing and sale of pharmaceuticals across the world. The company’s products are targe ...
; in 2007 Lundbeck and
entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate,
vortioxetine
Vortioxetine, sold under the brand names Trintellix and Brintellix among others, is a medication used to treat major depressive disorder. Effectiveness is viewed as similar to that of other antidepressants. It is taken by mouth.
Common side e ...
.
Tedatioxetine is reported to act as a
triple reuptake inhibitor (
serotonin >
norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad' ...
>
dopamine) and
5-HT2A,
5-HT2C,
5-HT3, and
α1A-adrenergic receptor antagonist.
As of 2009, it was in
phase II clinical trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, diet ...
s for
major depressive disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Intro ...
,
but there have been no updates since then, and as of August 2013 it was no longer displayed on Lundbeck's product pipeline.
On May 10, 2016, all work on tedatioxetine stopped.
A Chinese patent shows that there has been interest in this compound outside of Lundbeck.
See also
*
MIN-117
*
TGBA01AD
*
Vilazodone
Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder. It is taken by mouth.
Common side effects include nausea, diarrhea, and trouble sleeping. Serious side effects may include in ...
*
Vortioxetine
Vortioxetine, sold under the brand names Trintellix and Brintellix among others, is a medication used to treat major depressive disorder. Effectiveness is viewed as similar to that of other antidepressants. It is taken by mouth.
Common side e ...
References
External links
Lu AA24530 shows positive results in major depressive disorder phase II study
4-Piperidinyl compounds
Abandoned drugs
Antidepressants
Thioethers
{{Nervous-system-drug-stub