TROX-1

TROX-1 is a drug which acts as a potent calcium channel blocker, blocker of the Ca_v2 type Voltage-dependent calcium channel, calcium channels. It was developed as a potential analgesic after the discovery that the selective N-type calcium channel, Ca_v2.2 blocker ziconotide is an active analgesic with similar efficacy to strong opioid drugs. Unlike ziconotide, TROX-1 is not so selective, and also blocks the Cav2.1, Ca_v2.1 and R-type calcium channel, Ca_v2.3 calcium channel subtypes, but it has the great advantage of being orally active, whereas ziconotide must be administered intrathecally, by injection into the spinal fluid. In animal studies of TROX-1, analgesic effects were observed with similar efficacy to NSAIDs such as naproxen or diclofenac, and anti-allodynia effects equivalent to pregabalin or duloxetine.

References

Calcium channel blockers

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