TOX high mobility group box family member 2, also known as TOX2, is a human

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

. The

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

encoded by this gene is a member of a subfamily of

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...

s that also includes

TOX Tox or TOX may refer to: Science and technology * TOX, a protein encoded by the TOX gene * Tox screen, medical diagnostic screening for toxic substances Computing * Tox (protocol), peer-to-peer instant messaging software * tox (Python testing ...

TOX3 TOX high mobility group box family member 3, also known as ''TOX3'', is a human gene. The protein encoded by this gene is a member of a subfamily of transcription factors that also includes '' TOX'', ''TOX2'', and '' TOX4'' that share almost iden ...

, and

TOX4 TOX4 (TOX high mobility group box family member 4) also known as KIAA0737, is a human gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation' ...

that share almost identical

HMG-box In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding. Structure The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right). Function ...

DNA-binding domain A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a genera ...

s which function to modify

chromatin Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in r ...

structure.

References

Transcription factors {{gene-20-stub