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NM_005653
NM_001173452
NM_001173453

NM_001289603
NM_033476
NM_001355497

RefSeq (protein)

NP_001166923
NP_001166924
NP_005644

NP_001276532
NP_258437
NP_001342426

Location (UCSC) Chr 12: 51.09 – 51.17 Mb Chr 15: 100.5 – 100.55 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[5][6]

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1.[7] Late SV40 factor (LSF) also acts as an oncogene in hepatocellular carcinoma.[8] Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[9]

Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[8][10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.[8][10][11]

Interactions

TFCP2 has been shown to interact with APBB1[12] and RNF2.[13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135457 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009733 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. PMID 8157699. 
  6. ^ "Entrez Gene: TFCP2 transcription factor CP2". 
  7. ^ Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. doi:10.1073/pnas.0901451106. PMC 2722317Freely accessible. PMID 19622726. 
  8. ^ a b c Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. doi:10.1073/pnas.1000374107. PMC 2889542Freely accessible. PMID 20404171. 
  9. ^ Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi:10.1074/jbc.M111.298976. PMC 3270996Freely accessible. PMID 22167195. 
  10. ^ a b Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. 
  11. ^ Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. doi:10.1073/pnas.1121601109. PMC 3311344Freely accessible. PMID 22396589. Lay summaryScience Codex. 
  12. ^ Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356. 
  13. ^ Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618Freely accessible. PMID 11865070. 

Further reading