Angiopoietin-1 receptor also known as CD202B (
cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
202B) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''TEK''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Also known as TIE2, it is an
angiopoietin receptor
The angiopoietin receptors are receptors that bind angiopoietin.
TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors re ...
.
Function
The TEK receptor tyrosine kinase is expressed almost exclusively in
endothelial cell
The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel ...
s in mice, rats, and humans. (TEK is closely related to the
TIE receptor tyrosine kinase.)
This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats.
The ligand for the receptor is angiopoietin-1.
[ TEK has also been suggested as a marker for ]nucleus pulposus
An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold t ...
progenitor cells, from the intervertebral disc
An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold t ...
, which upon activation by Angiopoietin-1
Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from pre ...
starts to multiply and differentiate.
Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.[
In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.]
Interactions
TEK tyrosine kinase has been shown to interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
* ANGPT2
__NOTOC__
Angiopoietin-2 is a protein that in humans is encoded by the ''ANGPT2'' gene.
Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1
Function
* See A ...
,[
* ]Angiopoietin 1
Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific ty ...
,DOK2
Lee Joon-kyung (; born March 28, 1990) better known by his stage name Dok2 (, pronounced as Dokki), is a South Korean rapper, record producer and co-founder of now-defunct Illionaire Records.
Biography Early life
Dok2's mother is Korean, and h ...
.
See also
* Tie-2/Ang-1 signaling
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Multiple Cutaneous and Mucosal Venous Malformations
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{{DEFAULTSORT:Tek Tyrosine Kinase
Clusters of differentiation
Tyrosine kinase receptors