Transcription elongation factor A protein 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''TCEA1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic
transcription preinitiation complex
The preinitiation complex (abbreviated PIC) is a complex of approximately 100 proteins that is necessary for the transcription of protein-coding genes in eukaryotes and archaea. The preinitiation complex positions RNA polymerase II at gene trans ...
.
A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.
Interactions
TCEA1 has been shown to
interact
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with
GTF2H1
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the ''GTF2H1'' gene.
Interactions
GTF2H1 has been shown to Protein-protein interaction, interact with:
* Cyclin-dependent kinase 7,
* E2F1,
* ERCC2,
* Est ...
and
POLR2A
DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the ''POLR2A'' gene.
Function
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing m ...
.
References
Further reading
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