Study of Health in Pomerania
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The Study of Health in Pomerania (SHIP) is a population-based
epidemiological Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidenc ...
study consisting of two independent
cohorts Cohort or cohortes may refer to: * Cohort (educational group), a group of students working together through the same academic curriculum * Cohort (floating point), a set of different encodings of the same numerical value * Cohort (military unit), ...
(SHIP and SHIP-TREND). The SHIP investigates common
risk factor In epidemiology, a risk factor or determinant is a variable associated with an increased risk of disease or infection. Due to a lack of harmonization across disciplines, determinant, in its more widely accepted scientific meaning, is often use ...
s, subclinical disorders and manifest
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
s with highly innovative non-invasive methods in the high-risk population of northeast
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
. The study is not interested in one specific
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
. The SHIP study´s main aims include the investigation of
health Health, according to the World Health Organization, is "a state of complete physical, mental and social well-being and not merely the absence of disease and infirmity".World Health Organization. (2006)''Constitution of the World Health Organiza ...
in all its aspects and complexity involving the collection and assessment of
data In the pursuit of knowledge, data (; ) is a collection of discrete values that convey information, describing quantity, quality, fact, statistics, other basic units of meaning, or simply sequences of symbols that may be further interpreted ...
relevant to the prevalence and incidence of common, population-relevant
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
s and their
risk factor In epidemiology, a risk factor or determinant is a variable associated with an increased risk of disease or infection. Due to a lack of harmonization across disciplines, determinant, in its more widely accepted scientific meaning, is often use ...
s.


Design

The aims of both studies are: (i) investigation of the long-term progression of subclinical findings, their
determinant In mathematics, the determinant is a scalar value that is a function of the entries of a square matrix. It characterizes some properties of the matrix and the linear map represented by the matrix. In particular, the determinant is nonzero if and ...
s and prognostic values (SHIP-2); (ii) analysis of the secular trend of subclinical and overt
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
s and their
determinant In mathematics, the determinant is a scalar value that is a function of the entries of a square matrix. It characterizes some properties of the matrix and the linear map represented by the matrix. In particular, the determinant is nonzero if and ...
s in a high-risk population (SHIP-TREND vs SHIP-0); and (iii) assessment of the prevalence of subclinical findings (SHIP-TREND). For SHIP-0, a sample of 7008
women A woman is an adult female human. Prior to adulthood, a female human is referred to as a girl (a female child or Adolescence, adolescent). The plural ''women'' is sometimes used in certain phrases such as "women's rights" to denote female hum ...
and men aged 20 to 79 years was drawn in the cities of Greifswald,
Stralsund Stralsund (; Swedish: ''Strålsund''), officially the Hanseatic City of Stralsund (German: ''Hansestadt Stralsund''), is the fifth-largest city in the northeastern German federal state of Mecklenburg-Western Pomerania after Rostock, Schwerin, Neub ...
and
Anklam Anklam [], formerly known as Tanglim and Wendenburg, is a town in the Western Pomerania region of Mecklenburg-Vorpommern, Germany. It is situated on the banks of the Peene river, just 8 km from its mouth in the ''Kleines Haff'', the western ...
and 29 communities in the surrounding region which is part of
West Pomerania Historical Western Pomerania, also called Cispomerania, Fore Pomerania, Front Pomerania or Hither Pomerania (german: Vorpommern), is the western extremity of the historic region of Pomerania forming the southern coast of the Baltic Sea, Weste ...
, a region in the northeast of
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
, adjacent to the
Baltic Sea The Baltic Sea is an arm of the Atlantic Ocean that is enclosed by Denmark, Estonia, Finland, Germany, Latvia, Lithuania, Poland, Russia, Sweden and the North and Central European Plain. The sea stretches from 53°N to 66°N latitude and from ...
in the north and to the Polish border in the east.
West Pomerania Historical Western Pomerania, also called Cispomerania, Fore Pomerania, Front Pomerania or Hither Pomerania (german: Vorpommern), is the western extremity of the historic region of Pomerania forming the southern coast of the Baltic Sea, Weste ...
is the north-eastern part of
Mecklenburg-Vorpommern Mecklenburg-Vorpommern (MV; ; nds, Mäkelborg-Vörpommern), also known by its anglicized name Mecklenburg–Western Pomerania, is a state in the north-east of Germany. Of the country's sixteen states, Mecklenburg-Vorpommern ranks 14th in po ...
, one of the 16 federal German states. A separate stratified random sample of 8016
adult An adult is a human or other animal that has reached full growth. In human context, the term ''adult'' has meanings associated with social and legal concepts. In contrast to a " minor", a legal adult is a person who has attained the age of major ...
s aged 20–79 years was drawn for SHIP-TREND in the same area. Currently,
data In the pursuit of knowledge, data (; ) is a collection of discrete values that convey information, describing quantity, quality, fact, statistics, other basic units of meaning, or simply sequences of symbols that may be further interpreted ...
are collected for the second examination follow-up of the first SHIP
cohort Cohort or cohortes may refer to: * Cohort (educational group), a group of students working together through the same academic curriculum * Cohort (floating point), a set of different encodings of the same numerical value * Cohort (military unit), ...
(SHIP-2) and baseline examinations of the second SHIP
cohort Cohort or cohortes may refer to: * Cohort (educational group), a group of students working together through the same academic curriculum * Cohort (floating point), a set of different encodings of the same numerical value * Cohort (military unit), ...
(SHIP-TREND). SHIP-0: Data collection was conducted between October 1997 and May 2001. SHIP-1 follow-up examination: SHIP-0 participants were invited again. The first 5-year-follow-up was conducted between October 2002 and September 2006. SHIP-2 follow-up examination: The 11-year follow-up has started in June 2008 and was completed in
autumn Autumn, also known as fall in American English and Canadian English, is one of the four temperate seasons on Earth. Outside the tropics, autumn marks the transition from summer to winter, in September ( Northern Hemisphere) or March ( Sou ...
2012. SHIP-Trend-0: A new sample was drawn for a new
cohort Cohort or cohortes may refer to: * Cohort (educational group), a group of students working together through the same academic curriculum * Cohort (floating point), a set of different encodings of the same numerical value * Cohort (military unit), ...
, which was examined between September 2008 and
summer Summer is the hottest of the four temperate seasons, occurring after spring and before autumn. At or centred on the summer solstice, the earliest sunrise and latest sunset occurs, daylight hours are longest and dark hours are shortest, wit ...
2012.


Data collection

The following table shows all the instruments which are integrated in the SHIP examination.


Previous results

The West Pomeranian
population Population typically refers to the number of people in a single area, whether it be a city or town, region, country, continent, or the world. Governments typically quantify the size of the resident population within their jurisdiction using a ...
indicate a high prevalence of common
risk factor In epidemiology, a risk factor or determinant is a variable associated with an increased risk of disease or infection. Due to a lack of harmonization across disciplines, determinant, in its more widely accepted scientific meaning, is often use ...
s and
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
s. Especially
overweight Being overweight or fat is having more body fat than is optimally healthy. Being overweight is especially common where food supplies are plentiful and lifestyles are sedentary. , excess weight reached epidemic proportions globally, with mo ...
and
obesity Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's we ...
are more
prevalent In epidemiology, prevalence is the proportion of a particular population found to be affected by a medical condition (typically a disease or a risk factor such as smoking or seatbelt use) at a specific time. It is derived by comparing the number o ...
than in other German regions. Gallstone
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
s are very common and 30% of all
adult An adult is a human or other animal that has reached full growth. In human context, the term ''adult'' has meanings associated with social and legal concepts. In contrast to a " minor", a legal adult is a person who has attained the age of major ...
s suffer from
hepatic steatosis Fatty liver disease (FLD), also known as hepatic steatosis, is a condition where excess fat builds up in the liver. Often there are no or few symptoms. Occasionally there may be tiredness or pain in the upper right side of the abdomen. Complicat ...
. The prevalence of arterial
hypertension Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high bl ...
and left ventricular hypertrophy is much higher in the West Pomeranian
adult An adult is a human or other animal that has reached full growth. In human context, the term ''adult'' has meanings associated with social and legal concepts. In contrast to a " minor", a legal adult is a person who has attained the age of major ...
population Population typically refers to the number of people in a single area, whether it be a city or town, region, country, continent, or the world. Governments typically quantify the size of the resident population within their jurisdiction using a ...
. In the Northeast of
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
nearly 50% - 60% indicate these
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
s.


Magnetic resonance imaging (MRI)

SHIP is the first
population Population typically refers to the number of people in a single area, whether it be a city or town, region, country, continent, or the world. Governments typically quantify the size of the resident population within their jurisdiction using a ...
based cohort study worldwide which includes whole-body MRI. The aims of the following main whole body-MRI study are: (1)To provide prevalence estimates for different MR findings in a general
adult An adult is a human or other animal that has reached full growth. In human context, the term ''adult'' has meanings associated with social and legal concepts. In contrast to a " minor", a legal adult is a person who has attained the age of major ...
population Population typically refers to the number of people in a single area, whether it be a city or town, region, country, continent, or the world. Governments typically quantify the size of the resident population within their jurisdiction using a ...
. (2)To establish population-based MRI reference parameters for various
organs In biology, an organ is a collection of tissues joined in a structural unit to serve a common function. In the hierarchy of life, an organ lies between tissue and an organ system. Tissues are formed from same type cells to act together in a fu ...
and
organ Organ may refer to: Biology * Organ (biology), a part of an organism Musical instruments * Organ (music), a family of keyboard musical instruments characterized by sustained tone ** Electronic organ, an electronic keyboard instrument ** Hammond ...
parts such as left and right ventricular size or volume of
liver The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for ...
,
spleen The spleen is an organ found in almost all vertebrates. Similar in structure to a large lymph node, it acts primarily as a blood filter. The word spleen comes .
,
kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...
, prostate, and brain structures . Clinical MR reference parameters currently in use were derived from small, nonrepresentative samples and are thus prone to
selection bias Selection bias is the bias introduced by the selection of individuals, groups, or data for analysis in such a way that proper randomization is not achieved, thereby failing to ensure that the sample obtained is representative of the population int ...
. (3)To correlate MR findings with clinical examination results, metabolomic and genome-wide analysis in order to help elucidate the complex associations that exist between risk factors and diseases.


MRI Protocol

Additionally to the standard whole-body MRI protocol (right figure) men have the option to undergo contrast-enhanced cardiac MRI and MR angiography and
women A woman is an adult female human. Prior to adulthood, a female human is referred to as a girl (a female child or Adolescence, adolescent). The plural ''women'' is sometimes used in certain phrases such as "women's rights" to denote female hum ...
cardiac MRI and MR
mammography Mammography (also called mastography) is the process of using low-energy X-rays (usually around 30 kVp) to examine the human breast for diagnosis and screening. The goal of mammography is the early detection of breast cancer, typically through d ...
. Participants with a drug
allergy Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic derma ...
or allergy to any kind of contrast agent are excluded from the contrast-enhanced modules and only undergo standard protocol.


Assessment of Pathological Findings and Management

Two trained
radiologists Radiology ( ) is the medical discipline that uses medical imaging to diagnose diseases and guide their treatment, within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiatio ...
review all scans independently to evaluated images for presence or absence of pathological findings. In case of a difference between the two observer a third reading is performed to reach a consensus on the discrepant finding. Pathological findings are categorized using the method chosen by Bryan et al. for the Cardiovascular Health Study. This method classifies all findings into 4 basic categories. The management of pathological findings and communication with study participants are defined in a standardized protocol accepted by the local ethics committee. Participants with category IV findings are immediately transferred to a clinical specialist. Cases with positive findings of category II and III are referred to an Advisory Board established when the study began. and having as permanent members specialists from medical, surgical, neurological, epidemiological and radiological departments. Upon presentation of cases they reach a consensus about whether to recommend further clinical work-up or not. Participants in whom relevant findings are made get informed about the abnormality and recommendation of the Advisory Board.


Ship-Legende

SHIP-LEGEND stands for Life-Events and Gene-Environment interaction in Depression; its main aim is the identification of genetic factors which interact with stress and traumatic events to increase the risk of major depressive disorders. SHIP is the basis for this research. Between July 2007 and August 2010 n=2393 probands were interviewed. The interviewer assessed stress,
trauma Trauma most often refers to: *Major trauma, in physical medicine, severe physical injury caused by an external source *Psychological trauma, a type of damage to the psyche that occurs as a result of a severely distressing event *Traumatic inju ...
s and strains in childhood and
adult An adult is a human or other animal that has reached full growth. In human context, the term ''adult'' has meanings associated with social and legal concepts. In contrast to a " minor", a legal adult is a person who has attained the age of major ...
hood of the probands. Additionally diagnostic interviews were performed to diagnose current and lifetime mental disorders (DSM-IV). A broad range of
questionnaire A questionnaire is a research Research is "creativity, creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, ...
s were administered to assess e.g.
alexithymia Alexithymia is a personality trait characterized by the inability to identify and describe emotions experienced by oneself. The core characteristic of alexithymia is marked dysfunction in emotional awareness, social attachment, and interpersonal ...
(Toronto Alexithymia Scale 20), aversive childhood conditions (Childhood Trauma Questionnaire), depression (Beck Depression Inventory-2), resilience (RS-25) and personality traits (NEO-FFI).


Funding

SHIP is funded by following institutions: Federal Ministry of Education and Research, Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania, Federal Ministry of Nutrition, Agriculture and Consumer’s Safety,
German Research Foundation The German Research Foundation (german: Deutsche Forschungsgemeinschaft ; DFG ) is a German research funding organization, which functions as a self-governing institution for the promotion of science and research in the Federal Republic of Germ ...
, Competence Network Heart Failure, Competence Network Diabetes, German Asthma and COPD Network, Genopathomik, Alfried Krupp von Bohlen und Halbach Foundation, Alexander v. Humboldt Foundation, Leibniz Society,
Siemens Siemens AG ( ) is a German multinational conglomerate corporation and the largest industrial manufacturing company in Europe headquartered in Munich with branch offices abroad. The principal divisions of the corporation are ''Industry'', '' ...
AG, Health Care Sector (Erlangen, Germany), Pfizer Pharma GmbH (SBU Endocrinology and Ophthalmology; Berlin Germany),
Novo Nordisk Novo Nordisk A/S is a Danish multinational pharmaceutical company headquartered in Bagsværd, Denmark, with production facilities in nine countries, and affiliates or offices in five countries. Novo Nordisk is controlled by majority shareholder ...
(Mainz, Germany), Data Input GmbH (Darmstadt, Germany), GABA International AG (Therwil, Switzerland), Imedos Systems (Jena, Germany) and Heinen and Löwenstein (Bad Ems, Germany).


Publications

* Buch S, Schafmeyer C, Völzke H, Becker C, Franke A, von Eberstein H, Kluck C, Bäßmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Höll C, Seeger M, ElSharawy A, Fändrich F, Fölsch UR, Krawczak M, Schreiber S, Nürnberg P, Tepel J, Hampe J. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG5/ABCG8 as a susceptibility factor for human gallstone disease. Nat Genetics 2007;39:995-999 * Baumeister SE, Völzke H, Marschall P, John U, Schmidt CO, Alte D. Impact of fatty liver disease on health care utilization and costs in the general population: a 5-year observation. Gastroenterology 2008;134:85-94 * Desvarieux M, Schwahn C, Völzke H, Demmer RT, Lüdemann J, Kessler C, Jacobs DR, John U, Kocher T. Gender differences in the relationship between periodontal disease, tooth loss and atherosclerosis. Stroke 2004;35:2029-2035 * Döring A, Gieger C, Mehta D, Gohlke H, Prokisch H, Coassin S, Fischer G, Henke K, Klopp N, Kronenberg F, Paulweber B, Pfeufer A, Rosskopf D, Völzke H, Illig T, Meitinger T, Wichmann HE, Meisinger C. SLC2A9 influences uric acid concentrations with pronounced gender-specific effects. Nat Genetics 2008;40:430-436 * Dörr M, Wolff B, Robinson DM, John U, Lüdemann J, Meng W, Felix SB, Völzke H. The association of thyroid function with cardiac mass and left ventricular hypertrophy. J Clin Endocrinol Metab 2005;90:673-677 * Dörr M, Vogelgesang D, Robinson DM, Kors JA, Felix SB, Völzke H. Thyroid function is associated with short rate-adjusted QT intervals. Results from a population-based study. J Clin Endocrinol Metab 2006;91:4938-494 * Dörr M, Robinson DM, Wallaschofski H, Schwahn C, John U, Felix SB, Völzke H. Low serum thyrotropin is associated with high plasma fibrinogen. J Clin Endocrinol Metab 2006; 91: 530-534 * Friedrich N, Völzke H, Hampe J, Lerch M, Jorgensen T. Known risk factors do not explain disparities in gallstone prevalence between Denmark and Northeast Germany. Am J Gastroenterol 2009; 104: 89 - 95 * Friedrich N, Haring R, Nauck M, Lüdemann J, Spilcke-Liss E, Felix SB, Dörr M, Brabant G, Völzke H, Wallaschofski H. Serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and mortality: results of the Study of Health in Pomerania. J Clin Endocrinol Metab; in press * Gläser S, Friedrich N, Ewert R, Schäper C, Nauck M, Dörr M, Völzke H, Felix SB, Wallaschofski H, Koch B. Association between IGF-1 and IGFBP3 and lung function: results of the Study of Health in Pomerania. J Clin Endocrinol Metab; in press * Grabe HJ, Lange M, Wolff B, Völzke H, Alte D, Lucht M, Freyberger HJ, John U, Cascorbi I. Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatr 2005;10:220-224 * Grabe HJ, Spitzer C, Schwahn C, Barnow S, Lucht M, Freyberger HJ, John U, Wallaschofski H, Völzke H, Rosskopf D. The serotonin transporter gene promoter polymorphism (SLC6A4) and the susceptibility to posttraumatic stress disorder in the general population. Am J Psychiatr; in press * Haring R, Wallaschofski H, Nauck M, Dörr M, Baumeister SE, Völzke H. Ultrasonographic hepatic steatosis increased prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels. Hepatology; in press * Haring R, Völzke H, Felix SB, Schipf S, Dörr M, Rosskopf D, Nauck M, Schöfl C, Wallaschofski H. Prediction of metabolic syndrome by low serum testosterone levels in men: Results from the Study of Health in Pomerania. Diabetes; in press * Hegenscheid K, Kühn JP, Völzke H, Biffar R, Hosten N, Puls R. Whole-body magnetic resonance imaging of healthy volunteers: pilot study results from the population-based SHIP study. Rofo. 2009;181(8):748-59. * Houlston RS, Webb E, Broderick P, Pittman MA, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan j, Sullivan K, Penegar S, Carvajal-Carmona L, Howarth K, Jäger E, Spain S, Walther A, Barclay E, Martin L, Gorman M, Domingo E, Teixeira A, Kerr D, Cazier JB, Niittymäki I, Tuupanene S, Karhu A, Aaltonen L, Tomlinson IP, Farrington SM, Tenesa A, Prendergast JGD, Barnetson RA, Cetnarskyj R, Porteous ME, PD, Kössler T, Hampe J, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Chang-Claude J, Hoffmeister M, Brenner H, Zanke BW, Montpetit A, Hudson TJ, Gallinger S, Campbell H, Dunlop MG. Meta-analysis of genome-wide association data identifies 4 novel susceptibility loci for colorectal cancer. Nat Genetics 2008; 40: 1426 - 1435 * Koch B, Schäper C, Ittermann T, Spielhagen T, Völzke H, Ewert R, Gläser S. Reference values and ranges for cardiopulmonary exercise testing in a general adult population- results of the Study of Health in Pomerania. Eur Resp J 2009; 33: 389 - 397 * Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani N, Schlessinger D, Uda M, Völker U, Wäber G, Waterwoth D, Wang-Sattler R, Writh AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H, Döring A, Wichmann HE, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M, Illig T, Gieger C. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLOS Genetics; in press * Meisinger C, Heier M, Völzke H, Löwel H, Mitusch R, Lüdemann J, Hense HW. Regional disparities of hypertension prevalence and management within Germany. J Hypertens 2006; 24: 293-299 * Meisinger C, Gieger C, Prokisch H, Soranzo Z, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Ouwehand WH, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, Völzke H, Peters A, Illig T, Meitinger T, Wichmann HE, Döring A. A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet 2009; 84: 66 - 71 * * Puls R, Hosten N. (Hrgs.) Zufallsbefunde in der Ganzkörper-MRT. ABW Wissenschaftsverlag Berlin 2010, * Puls R, Hamm B, Hosten N. MRT ohne Radiologen - Ethische Aspekte bei bevölkerungsbasierten Studien mit MR-Untersuchungen. Rofo. 2010; 182:469-471 *Schmidt CO, Alte D, Sauer S, Völzke H, Friedrich N, Valliant R. (in press) Partial misspecification of survey design features sufficed to severely bias estimates of health related outcomes. J Clin Epidemiology. * Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett MS, Devaney J, Döring A, Elosua R, Epstein S, Erber W, Falchi M, Garner SF, Ghori MJ, Goodall AH, Gwilliam R, Hall AS, Hammond N, Hengstenberg C, Illig T, König IR, Knouff CR, McPherson R, Melander O, Mooser V, Nauck M, Nieminen MS, O’Donnell CJ, Peltonen L, Potter SC, Prokisch H, Rader DJ, Rice CM, Roberts R, Salomaa V, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Stark K, Stephens J, Thompson JR, Völker U, Völzke H, Watkins NA, Wells GA, Wichmann HE, Heel DV, Tyler-Smith C, Thein SL, Kathiresan S, Perola M, Reilly MP, Stewart AF, Erdmann J, Samani NJ, Meisinger C, Greinacher A, Deloukas P, Ouwehand WH, Gieger C. A meta-analysis of eight haematological parameters identifies 22 associated loci and extensive disease pleiotropy on chromosome 12q24. Nat Genetics, in press * Spitzer C, Barnow S, Völzke H, John U, Freyberger HJ, Grabe HJ. Trauma and Postraumatic Stress Disorder in an elderly community sample. J Clin Psychiatr 2008;69:693-700 * Tenesa A, Farrington SM, Prendergast JGD, Porteous ME, Walker M, Haq N, Barnetson RA, Theodoratou E, Cetnarskyj R, Cartwright N, Wilson R, Semple C, Clarke AJ, Reid FJL, Smith LA, Kavoussanakis K, Kossler T, PDP, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Schmidt CO, Hampe J, Wilkening S, Canzian F, Chang-Claude J, Hoffmeister M, Brenner H, Capella G, Moreno V, Deary IJ, Starr JM, Tomlinson IPM, Webb E, Houlston RS, Rennert G, Ballinger D, Rozek L, Gruber SB, Matsuda K, Kidokoro T, Nakamura Y, Zanke BW, Greenwood CMT, Rangrej J, Kustra R, Montpetit A, Hudson TJ, Gallinger S, Campbell H, Dunlop MG. A genome-wide association scan identifies three colorectal cancer susceptibility loci. Nat Genetics 2008;40:631-637 * Tomlinson IPM, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman AM, Spain S, Lubbe S, Walther A, Sullivan K, Jaeger E, Fielding S, Rowan A, Vijayakrishnan J, Domingo E, Chandler I, Kemp Z, Qureshi M, Farrington SM, Tenesa A, Prendergast JGD, Bametson RA, Penegar S, Barclay E, Wood W, Martin L, Gorman M, Thomas H, Peto J, Bishop DT, Gray R, Maher ER, Lucassen A, Kerr D, Evans DGR, The CORGI Consortium, Schafmeyer C, Buch S, Völzke H, Hampe J, Schreiber S, John U, Kössler T, P, van Wezel T, Morreau H, Wijnen JT, Hopper JL, Southey MC, Giles GG, Severi G, Catellvi-Bel S, Ruiz-Ponte C, Carracedo A, Castells A, The EPICOLON Consortium, Foersti A, Hemminki K, Vodicka P, Naccarati A, Lipton L, Ho JWC, Cheng KK, Sham PC, Luk J, Agundez JAG, Ladero JM, de la Hoya M, Caldés T, Niittymäki I, Tuupanene S, Karhu A, Aaltonen L, Cazier JB, Campbell H, Dunlop MG, Houlston RS. A genome-wide association study identifies novel colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genetics 2008;40:623-630 * Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Großhennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, König IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira J, Erdmann J, Dörr M, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, Völker U, Ingelsson E, Iftikhar K, Härting J, O’Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Rice K, Arnett D, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, Völzke H, Blankenberg S. Novel genetic variants associated with cardiac structure and function: Genome-wide association findings of a prospective meta-analysis from the EchoGen Consortium. JAMA; in press * Völzke H, Robinson DM, Schminke U, Lüdemann J, Rettig R, Felix SB, Kessler C, John U, Meng W. Thyroid function and carotid wall thickness. J Clin Endocrinol Metab 2004;89:2145-2149 * Völzke H, Werner A, Wallaschofski H, Friedrich N, Robinson DM, Kindler S, Kraft M, John U, Hoffmann W. Occupational exposure to ionizing radiation is associated with autoimmune thyroid disease. J Clin Endocrinol Metab 2005;90:4587-4592 * Völzke H, Warnke C, Dörr M, Kramer A, Gürtler L, Hoffmann W, Kors JA, John U, Felix SB. Prior history of diphtheria and current cardiac disorders. Eur J Clin Microbiol Infect Dis 2006; 25: 651-656 * Völzke H, Schwahn C, Dörr M, Schwarz S, Robinson D, Dören M, Felix SB, John U, Kocher T. Gender differences in the relation between number of teeth and systolic blood pressure. J Hypertens 2006; 24: 1257-1263 * Völzke H, Hoffmann W. cientific letterRadiation exposure and thyroid disorders in Hiroshima and Nagasaki atomic bomb survivors. JAMA 2006;296:512-513 * Völzke H, Alte D, Dörr M, Wallaschofski H, John U, Felix SB, Rettig R. The association between subclinical hyperthyroidism and blood pressure in a population-based study. J Hypertens 2006;24:1947-1953 * Völzke H. Mortality in patients with hepatitis B or hepatitis C. Lancet 2006;368:1767 cientific letter* Völzke H, Schwarz S, Baumeister SE, Wallaschofski H, Schwahn C, Grabe HJ, Kohlmann T, John U, Dören M. Menopausal status and hepatic steatosis in a general female population. Gut 2007; 56: 594-595 * Völzke H, Friedrich N, Schipf S, Haring R, Lüdemann J, Nauck M, Dörr M, Brabant G, Wallaschofski H. Association between serum IGF-1 levels and thyroid disorders in a population-based study. J Clin Endocrinol Metab 2007;92:4039-4045 * Völzke H. Hyperthyroidism and mortality. cientific letter J Am Coll Cardiol 2007;49:2229-2230 * Völzke H, Robinson D, Spielhagen T, Nauck M, Obst A, Ewert A, Wolff B, Wallaschofski H, Felix SB, Dörr M. Serum thyrotropin levels within the reference range are associated with endothelial function. Eur Heart J 2009; 30: 217 – 224 * Wolff B, Völzke H, Lüdemann J, Robinson DM, Vogelgesang D, Staudt A, Kessler C, Dahm JB, John U, Felix SB. Association between high serum ferritin levels and carotid atherosclerosis in the Study of Health in Pomerania (SHIP). Stroke 2004;35:453 - 457 * Wolff B, Völzke H, Robinson D, Schwahn C, Vogelgesang D, Dahm JB, Kessler C, John U, Felix SB. Relation of parity with common carotid intima-media thickness among women of the Study of Health in Pomerania (SHIP). Stroke 2005;36:938-943


References

* Völzke H, Alte D, Schmidt CO ''et al.'' (2009). "Cohort Profile: The Study of Health in Pomerania". International Journal of Epidemiology;1–14. * John U ''et al.'' (2001). "Study of Health in Pomerania (SHIP) - A health examination survey in an east German region: Objectives and design". Sozial- und Präventivmedizin 46(3): 186-194. *Bryan RN, Manolio TA, Schertz LD et al.(1994). "A method for using MR to evaluate the effects of cardiovascular disease on the brain: the cardiovascular health study". AJNR Am J Neuroradiol;15:1625-1633.


External links


Study of Health in Pomerania (SHIP)- official homepageGreifswald Approach to Individualized Medicine (GANI_MED)- official homepageInstitut für Community Medicine
{{DEFAULTSORT:Study Of Health In Pomerania Pomerania Public health research Epidemiological study projects