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NM_003146

NM_001136081
NM_182990

RefSeq (protein)

NP_003137

NP_001129553
NP_892035

Location (UCSC) Chr 11: 57.33 – 57.34 Mb Chr 2: 85.04 – 85.05 Mb PubMed search [3] [4] Wikidata
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FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.[5]

Function

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.[5]

Interactions

Structure specific recognition protein 1 has been shown to interact with NEK9.[6] SSRP1 further interacts with transcriptional activator p63.[7] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149136 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027067 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: SSRP1 structure specific recognition protein 1". 
  6. ^ Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563. 
  7. ^ Zeng SX, Dai MS, Keller DM, Lu H (15 Oct 2002). "SSRP1 functions as a co-activator of the transcriptional activator p63". EMBO J. 21 (20): 5487–97. doi:10.1093/emboj/cdf540. PMC 129072Freely accessible. PMID 12374749. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.