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The Strategic National Stockpile (SNS), originally called the National Pharmaceutical Stockpile (NPS), is the United States' national repository of antibiotics, vaccines, chemical antidotes, antitoxins, and other critical medical supplies.

The Office of the Assistant Secretary for Preparedness and Response (ASPR) of the Department of Health and Human Services has managed the Strategic National Stockpile since October 1, 2018. Prior to that, the stockpile was managed by the Centers for Disease Control and Prevention (CDC).

As of 2020, the SNS contains around $7–8 billion worth of emergency supplies stored in secret warehouses located strategically around the country.[1][2] By March 10, 2020, it was reported that the COVID-19 pandemic had already "placed significant strain on the stores of masks, medicine, and medical equipment" found in the stockpile.[2]

Prior to April 3, 2020 the role of the stockpile was to support state, local, tribal, and territorial responders providing potentially life-saving pharmaceuticals and medical supplies for use in a public health emergency severe enough to cause local supplies to run out. Its current role is to act as a national supplement of medicine and medical equipment to a State's supplies, acting as a "stopgap buffer" when "the immediate supply of adequate amounts of these materials may not be immediately available."[3][4][5]