Stenting
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medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pr ...
, a stent is a metal or plastic tube inserted into the lumen of an anatomic vessel or duct to keep the passageway open, and stenting is the placement of a stent. A wide variety of stents are used for different purposes, from expandable
coronary Coronary () may, as shorthand in English, be used to mean: * Coronary circulation, the system of arteries and veins in mammals ** Coronary artery disease **Coronary occlusion ** A myocardial infarction, a heart attack As adjective * Referring to ...
,
vascular The blood vessels are the components of the circulatory system that transport blood throughout the human body. These vessels transport blood cells, nutrients, and oxygen to the tissues of the body. They also take waste and carbon dioxide away f ...
and
biliary A bile duct is any of a number of long tube-like structures that carry bile, and is present in most vertebrates. Bile is required for the digestion of food and is secreted by the liver into passages that carry bile toward the hepatic duct. It ...
stents, to simple plastic stents that allow
urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra. Cellular ...
to flow between
kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blo ...
and
bladder The urinary bladder, or simply bladder, is a hollow organ in humans and other vertebrates that stores urine from the kidneys before disposal by urination. In humans the bladder is a distensible organ that sits on the pelvic floor. Urine enters ...
. "Stent" is also used as a
verb A verb () is a word ( part of speech) that in syntax generally conveys an action (''bring'', ''read'', ''walk'', ''run'', ''learn''), an occurrence (''happen'', ''become''), or a state of being (''be'', ''exist'', ''stand''). In the usual descr ...
to describe the placement of such a device, particularly when a disease such as
atherosclerosis Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheromatous plaque. At onset there are usually no s ...
has pathologically narrowed a structure such as an
artery An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pu ...
. A stent is different from a shunt. A shunt is a tube that connects two previously unconnected parts of the body to allow fluid to flow between them. Stents and shunts can be made of similar materials, but perform two different tasks.


Stent types


Etymology

The current accepted origin of the word ''stent'' is that it derives from the name of an English dentist, Charles Thomas Stent (1807–1885), notable for his advances in the field of denture-making. He was born in Brighton, England, on October 17, 1807, was a dentist in London, and is most famous for improving and modifying the denture base of the
gutta-percha Gutta-percha is a tree of the genus ''Palaquium'' in the family Sapotaceae. The name also refers to the rigid, naturally biologically inert, resilient, electrically nonconductive, thermoplastic latex derived from the tree, particularly from ...
, creating the stent's compounding that made it practical as a material for dental impressions. Others attribute the noun ''stent'' to
Jan F. Esser Johannes "Jan" Fredericus Samuel Esser (13 October 1877 in Leiden – 9 August 1946 in Chicago) was a Dutch plastic surgeon who pioneered innovative methods of reconstructive surgery on soldiers wounded in the First World War. He is thought to ha ...
, a Dutch plastic surgeon who in 1916 used the word to describe a dental impression compound invented in 1856 by Charles Stent, whom Esser employed to craft a form for facial reconstruction. The full account is described in the ''Journal of the History of Dentistry''. According to the author, from the use of Stent's compound as a support for facial tissues evolved the use of a stent to hold open various body structures. The verb form "stenting" was used for centuries to describe the process of stiffening garments (a usage long obsolete, per the ''
Oxford English Dictionary The ''Oxford English Dictionary'' (''OED'') is the first and foundational historical dictionary of the English language, published by Oxford University Press (OUP). It traces the historical development of the English language, providing a co ...
''), and some believe this to be the origin. According to the Merriam Webster Third New International Dictionary, the noun evolved from the Middle English verb ''stenten'', shortened from ''extenten'' 'to stretch', which in turn came from Latin ''extentus'', the past participle of ''extendō'' 'to stretch out'. The first (self-expanding) "stents" used in medical practice in 1986 by
Ulrich Sigwart Ulrich Sigwart (; born 9 March 1941) is a German retired cardiologist known for his pioneering role in the conception and clinical use of stents to keep blood vessels open, and introducing a non-surgical intervention, alcohol septal ablation for ...
in Lausanne were initially called "Wallstents" after their inventor, Hans Wallstén.
Julio Palmaz Julio Palmaz (December 13, 1945 in La Plata, Argentina) is a doctor of vascular radiology at University of Texas Health Science Center at San Antonio. He studied at the National University of La Plata in Argentina, earning his medical degree in ...
''et al.'' created a balloon-expandable stent that is currently used.


History

The first use of a coronary stent is typically attributed to and
Ulrich Sigwart Ulrich Sigwart (; born 9 March 1941) is a German retired cardiologist known for his pioneering role in the conception and clinical use of stents to keep blood vessels open, and introducing a non-surgical intervention, alcohol septal ablation for ...
, who implanted a stent into a patient in Toulouse, France, in 1986. That stent was used as a scaffold to prevent a vessel from closing and to avoid
restenosis Restenosis is the recurrence of stenosis, a narrowing of a blood vessel, leading to restricted blood flow. Restenosis usually pertains to an artery or other large blood vessel that has become narrowed, received treatment to clear the blockage and s ...
in coronary surgery—a condition where scar tissue grows within the stent and interferes with vascular flow. Shortly thereafter, in 1987,
Julio Palmaz Julio Palmaz (December 13, 1945 in La Plata, Argentina) is a doctor of vascular radiology at University of Texas Health Science Center at San Antonio. He studied at the National University of La Plata in Argentina, earning his medical degree in ...
(known for patenting a balloon-expandable stent ) and Richard Schatz implanted their similar stent into a patient in Germany. Though several doctors have been credited with the creation of the stent, the first
FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...
-approved stent in the U.S. was created by Richard Schatz and coworkers. Named the Palmaz-Schatz ( Johnson & Johnson), it was developed in 1987. To further reduce the incidence of restenosis, the
drug-eluting stent A drug-eluting stent (DES) is a peripheral or coronary stent (a scaffold) placed into narrowed, diseased peripheral or coronary arteries that slowly release a drug to block cell proliferation. This prevents fibrosis that, together with clots ( ...
was introduced in 2003. Research has led to general stent design changes and improvements since that time. Bioresorbable scaffolds have also entered the market, though a large-scale clinical trial showed higher acute risks compared to drug-eluding stents. As a result, the FDA issued an official warning for their use in 2013, and research on the design and performance optimisation of stents is ongoing.


See also

*
Bioresorbable stent In medicine, a stent is any device which is inserted into a blood vessel or other internal duct to expand it to prevent or alleviate a blockage. Traditionally, such devices are fabricated from metal mesh and remain in the body permanently or unti ...
*
Bronchoscopy Bronchoscopy is an endoscopic technique of visualizing the inside of the airways for diagnostic and therapeutic purposes. An instrument (bronchoscope) is inserted into the airways, usually through the nose or mouth, or occasionally through a trac ...
* Colonoscopy * Esophagogastroduodenoscopy *
Grommet Curtain grommets, used among others in shower curtains. A grommet is a ring or edge strip inserted into a hole through thin material, typically a sheet of textile fabric, sheet metal or composite of carbon fiber, wood or honeycomb. Grommets ar ...
* Interventional radiology


References


External links


Coronary Stent



Cardiovascular and Interventional Radiological Society of Europe

The Cardiovascular Forum

Stent for Life Initiative
{{Authority control Implants (medicine) Interventional radiology Medical devices