Stanley Cohen (November 17, 1922 – February 5, 2020) was an American biochemist who, along with

Rita Levi-Montalcini Rita Levi-Montalcini (, ; 22 April 1909 – 30 December 2012) was an Italian Nobel laureate, honored for her work in neurobiology. She was awarded the 1986 Nobel Prize in Physiology or Medicine jointly with colleague Stanley Cohen for the ...

, was awarded the

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute, Nobel Assembly at the Karolinska Institutet, Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Pr ...

in 1986 for the isolation of

nerve growth factor Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was on ...

and the discovery of

epidermal growth factor Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-k Da and has 53 amino acid residues and three intramolecular disulfide bonds. EGF was originally descr ...

. He died in February 2020 at the age of 97.

Early life and education

Cohen was born in Brooklyn, New York, on November 17, 1922. He was the son of Fannie (née Feitel) and Louis Cohen, a tailor. His parents were Jewish immigrants. Cohen received his

bachelor's degree A bachelor's degree (from Middle Latin ''baccalaureus'') or baccalaureate (from Modern Latin ''baccalaureatus'') is an undergraduate academic degree awarded by colleges and universities upon completion of a course of study lasting three to six ...

in 1943 from

Brooklyn College Brooklyn College is a public university in Brooklyn, Brooklyn, New York. It is part of the City University of New York system and enrolls about 15,000 undergraduate and 2,800 graduate students on a 35-acre campus. Being New York City's first publ ...

, where he had double-majored in

chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

and

biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...

. After working as a

bacteriologist A bacteriologist is a microbiologist, or similarly trained professional, in bacteriology -- a subdivision of microbiology that studies bacteria, typically Pathogenic bacteria, pathogenic ones. Bacteriologists are interested in studying and learnin ...

at a milk processing plant to earn money, he received his

Master of Arts A Master of Arts ( la, Magister Artium or ''Artium Magister''; abbreviated MA, M.A., AM, or A.M.) is the holder of a master's degree awarded by universities in many countries. The degree is usually contrasted with that of Master of Science. Tho ...

zoology Zoology ()The pronunciation of zoology as is usually regarded as nonstandard, though it is not uncommon. is the branch of biology that studies the Animal, animal kingdom, including the anatomy, structure, embryology, evolution, Biological clas ...

from

Oberlin College Oberlin College is a Private university, private Liberal arts colleges in the United States, liberal arts college and conservatory of music in Oberlin, Ohio. It is the oldest Mixed-sex education, coeducational liberal arts college in the United S ...

in 1945. He earned a

doctorate A doctorate (from Latin ''docere'', "to teach"), doctor's degree (from Latin ''doctor'', "teacher"), or doctoral degree is an academic degree awarded by universities and some other educational institutions, derived from the ancient formalism ''l ...

from the department of biochemistry about the metabolism of earthworms at the

University of Michigan , mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As o ...

in 1948.

Career

His first academic employment was at the University of Colorado studying the metabolism of premature babies. In 1952 he moved to

Washington University in St. Louis Washington University in St. Louis (WashU or WUSTL) is a private research university with its main campus in St. Louis County, and Clayton, Missouri. Founded in 1853, the university is named after George Washington. Washington University is r ...

, working first in the Department of Radiology, learning isotope methodology, and then in the Department of Zoology. Working with

, he isolated nerve growth factor. He later isolated a protein that could accelerate incisor eruption and eyelid opening in newborn mice, which was renamed epidermal growth factor. He continued research on cellular growth factors after joining the faculty of Vanderbilt University School of Medicine in 1959. In 1999, Cohen retired from Vanderbilt University.

Awards and legacy

Cohen received the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

together with Rita Levi-Montalcini in 1983, the

in 1986 for the isolation of

and the discovery of

and the

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...

in 1986. His research on cellular growth factors has proven fundamental to understanding the development of

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

and designing anti-cancer drugs. His Scopus ''h''-index value was 82 as of March 2022.

References

External links

* including the Nobel Lecture 8 December 1986 ''Epidermal Growth Factor''
Stanley Cohen Nobel link

The Official Site of Louisa Gross Horwitz Prize
{{DEFAULTSORT:Cohen, Stanley 1922 births 2020 deaths Nobel laureates in Physiology or Medicine American Nobel laureates American biochemists Members of the United States National Academy of Sciences James Madison High School (Brooklyn) alumni Jewish American scientists Jewish chemists Jewish physicians National Medal of Science laureates Oberlin College alumni Brooklyn College alumni Washington University in St. Louis faculty Nobel laureates affiliated with Missouri Vanderbilt University faculty University of Michigan College of Literature, Science, and the Arts alumni Recipients of the Albert Lasker Award for Basic Medical Research