Spoo may refer to:
*
Bob Spoo
Robert Allen Spoo (November 2, 1937 – October 15, 2018) was an American college football coach. He served as the head football coach at Eastern Illinois University from 1987 to 2011 (with an interruption in 2006 due to surgery), compiling a re ...
(1937–2018), an American college football coach
*
Caspar Mathias Spoo (1837–1914), a Luxembourgish industrialist and politician
* Spoo, a fictional food in the ''
Babylon 5
''Babylon 5'' is an American space opera television series created by writer and producer J. Michael Straczynski, under the Babylonian Productions label, in association with Straczynski's Synthetic Worlds Ltd. and Warner Bros. Domestic Tele ...
'' science fiction television series
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