Sir Paul Maxime Nurse (born 25 January 1949) is an English

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processes ...

, former

President of the Royal Society The president of the Royal Society (PRS) is the elected Head of the Royal Society of London who presides over meetings of the society's council. After informal meetings at Gresham College, the Royal Society was officially founded on 28 November ...

and Chief Executive and Director of the Francis Crick Institute. He was awarded the 2001

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

along with

Leland Hartwell Leland Harrison (Lee) Hartwell (born October 30, 1939 in Los Angeles, California) is former president and director of the Fred Hutchinson Cancer Research Center in Seattle, Washington. He shared the 2001 Nobel Prize in Physiology or Medicine wit ...

and

Tim Hunt Sir Richard Timothy Hunt, (born 19 February 1943) is a British biochemist and molecular physiologist. He was awarded the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Leland H. Hartwell for their discoveries of protein molec ...

for their discoveries of protein molecules that control the division of cells in the

cell cycle The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and sub ...

Early life and education

Nurse's mother went from

London London is the capital and List of urban areas in the United Kingdom, largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary dow ...

Norwich Norwich () is a cathedral city and district of Norfolk, England, of which it is the county town. Norwich is by the River Wensum, about north-east of London, north of Ipswich and east of Peterborough. As the seat of the See of Norwich, with ...

Norfolk Norfolk () is a ceremonial and non-metropolitan county in East Anglia in England. It borders Lincolnshire to the north-west, Cambridgeshire to the west and south-west, and Suffolk to the south. Its northern and eastern boundaries are the No ...

and lived with relatives while awaiting Paul's birth (at the age of 18) in order to hide

illegitimacy Legitimacy, in traditional Western common law, is the status of a child born to parents who are legally married to each other, and of a child conceived before the parents obtain a legal divorce. Conversely, ''illegitimacy'', also known as '' ...

. For the rest of their lives his maternal grandmother pretended to be his mother and his mother pretended to be his sister. Paul was brought up by his grandparents (whom he took to be his parents) in North West London. He was educated at Lyon Park school in

Alperton Alperton () is an area of north west London, England, within the London Borough of Brent. It forms the southern part of the town of Wembley and is west north-west of Charing Cross. It includes a handful of high-rise and many mid-rise buildings ...

and Harrow County Grammar School. He received his

BSc A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University ...

degree in

biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...

in 1970 from the

University of Birmingham The University of Birmingham (informally Birmingham University) is a Public university, public research university located in Edgbaston, Birmingham, United Kingdom. It received its royal charter in 1900 as a successor to Queen's College, Birmingha ...

and his PhD degree in 1973 from the

University of East Anglia The University of East Anglia (UEA) is a public research university in Norwich, England. Established in 1963 on a campus west of the city centre, the university has four faculties and 26 schools of study. The annual income of the institution f ...

for research on ''

Candida utilis Torula (''Cyberlindnera jadinii'') is a species of yeast. Use Torula, in its inactive form (usually labeled as torula yeast), is widely used as a flavoring in processed foods and pet foods. It is often grown on wood liquor, a byproduct of paper ...

''. He then pursued postdoctoral work at the

University of Bern The University of Bern (german: Universität Bern, french: Université de Berne, la, Universitas Bernensis) is a university in the Swiss capital of Bern and was founded in 1834. It is regulated and financed by the Canton of Bern. It is a compreh ...

, the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...

and the

University of Sussex , mottoeng = Be Still and Know , established = , type = Public research university , endowment = £14.4 million (2020) , budget = £319.6 million (2019–20) , chancellor = Sanjeev Bhaskar , vice_chancellor = Sasha Roseneil , ...

. Nurse did not know that his "sister" was in fact his mother until he was in his 50s: his application for a

green card A green card, known officially as a permanent resident card, is an identity document which shows that a person has permanent residency in the United States. ("The term 'lawfully admitted for permanent residence' means the status of having been ...

for US residency while president of Rockefeller University was, to his surprise, rejected, despite his being a Nobel Prize winner, president of a university and a knight; this was because he had submitted a short-form UK birth certificate which did not name his parents. When he applied for a full birth certificate he discovered the truth, to his astonishment.

Career and research

Nurse continued his

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

at the laboratory of

Murdoch Mitchison The Honounorable John Murdoch Mitchison FRS, FRSE (11 June 1922, Oxford – 17 March 2011, Edinburgh) was a British zoologist. Background Family Mitchison was the son of the Labour politician Dick Mitchison and his wife, the writer Naomi ...

at the

for the next six years (1973–1979). including the Nobel Lecture Nobel Lecture 9 December 2001 ''Controlling the Cell Cycle'' Beginning in 1976, Nurse identified the gene ''

cdc2 Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in th ...

'' in

fission yeast ''Schizosaccharomyces pombe'', also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology. It is a unicellular eukaryote, whose cells are rod-shaped. Cells typically m ...

(''

Schizosaccharomyces pombe ''Schizosaccharomyces pombe'', also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology. It is a unicellular eukaryote, whose cells are rod-shaped. Cells typically measur ...

''). This gene controls the progression of the cell cycle from

G1 phase The G1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps lead ...

to S phase and the transition from

G2 phase G2 phase, Gap 2 phase, or Growth 2 phase, is the third subphase of interphase in the cell cycle directly preceding mitosis. It follows the successful completion of S phase, during which the cell’s DNA is replicated. G2 phase ends with the ...

to mitosis. In 1987, Nurse identified the homologous gene in human, ''

Cdk1 Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in t ...

'', which codes for a cyclin dependent kinase. Working in fission yeast, Nurse identified the gene cdc2, which controls the transition from G1 to S, when the cell grows in preparation for the duplication of DNA, and G2 to M, when the cell divides. With his postdoc

Melanie Lee Melanie Georgina Lee CBE (born 29 July 1958) is an English pharmaceutical industry executive and CEO of LifeArc, succeeding Dave Tapolczay in November 2018. Career Research Lee received an undergraduate degree in Biology from the University ...

, Nurse also found the corresponding gene, CDK1, in humans. These genes stop and start cyclin dependent kinase (CDK) by adding or removing phosphate groups. In 1984, Nurse joined the

Imperial Cancer Research Fund Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

(ICRF, now

Cancer Research UK Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

). He left in 1988 to chair the department of microbiology at the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

. He then returned to the ICRF as Director of Research in 1993, and in 1996 was named Director General of the ICRF, which became Cancer Research UK in 2002. In 2003, he became president of Rockefeller University in

New York City New York, often called New York City or NYC, is the most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the most densely populated major city in the Un ...

where he continued work on the cell cycle of fission yeast. In 2011 Nurse became the first Director and Chief Executive of the UK Centre for Medical Research and Innovation, now the Francis Crick Institute. On 30 November 2010, Nurse succeeded astrophysicist

Martin Rees Martin John Rees, Baron Rees of Ludlow One or more of the preceding sentences incorporates text from the royalsociety.org website where: (born 23 June 1942) is a British cosmologist and astrophysicist. He is the fifteenth Astronomer Royal, ...

for a five-year term as

until 2015. Nurse has said good scientists must have passion "to know the answer to the questions" that interest them, along with good technical ability, and a set of attitudes including mental honesty, self-criticism, open-mindedness and scepticism.

Awards and honours

In addition to the Nobel Prize, Nurse has received numerous awards and honours. He was elected an

EMBO Member Membership of the European Molecular Biology Organization (EMBO) is an award granted by the European Molecular Biology Organization (EMBO) in recognition of "research excellence and the outstanding achievements made by a life scientist". , 88 EMB ...

in 1987 and a Fellow of the Royal Society (FRS) in 1989 and the Founder Member of the

Academy of Medical Sciences The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to adv ...

in 1998. In 1995, he was awarded the Pezcoller-AACR International Award. he received a Royal Medal and became a foreign associate of the U.S. National Academy of Sciences. He received the Albert Lasker Award for Basic Medical Research in 1998. Nurse was knighted in 1999. He was awarded the French

Legion d'Honneur The National Order of the Legion of Honour (french: Ordre national de la Légion d'honneur), formerly the Royal Order of the Legion of Honour ('), is the highest French order of merit, both military and civil. Established in 1802 by Napoleon B ...

and the Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...

in 2002. He was also awarded the Copley Medal in 2005. He was elected a Foreign Honorary Member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

– one of the top honours – in April 2006. He is a member of the Advisory Council for the Campaign for Science and Engineering. Nurse is the 2007 recipient of the Hope Funds Award of Excellence in Basic Research. He is a Freeman of the London Borough of Harrow. In 2013, he was awarded the

Albert Einstein World Award of Science The Albert Einstein World Award for Science is an annual award given by the World Cultural Council "as a means of recognition and encouragement for scientific and technological research and development", with special consideration for researches ...

by the

World Cultural Council The World Cultural Council is an international organization whose goals are to promote cultural values, goodwill and philanthropy among individuals. The organization founded in 1981 and based in Mexico, has held a yearly award ceremony since 198 ...

. In 2015, he was elected a foreign academician of the

Chinese Academy of Sciences The Chinese Academy of Sciences (CAS); ), known by Academia Sinica in English until the 1980s, is the national academy of the People's Republic of China for natural sciences. It has historical origins in the Academia Sinica during the Republi ...

, and won the 10th annual Henry G. Friesen International Prize in Health Research, in Ottawa, Canada. He was appointed

Member of the Order of the Companions of Honour The Order of the Companions of Honour is an order of the Commonwealth realms. It was founded on 4 June 1917 by King George V as a reward for outstanding achievements. Founded on the same date as the Order of the British Empire, it is sometimes ...

(CH) in the

2022 New Year Honours The 2022 New Year Honours are appointments by some of the 15 Commonwealth realms to various orders and honours to recognise and reward good works by citizens of those countries. The New Year Honours are awarded as part of the New Year celebrations ...

for services to science and medicine in the UK and abroad. In November 2022 he was appointed to the Order of Merit. Nurse has received over 60 Honorary Degrees and Fellowships, including from the

University of Bath (Virgil, Georgics II) , mottoeng = Learn the culture proper to each after its kind , established = 1886 (Merchant Venturers Technical College) 1960 (Bristol College of Science and Technology) 1966 (Bath University of Technology) 1971 (univ ...

in 2002, the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

in 2003, the

University of Cambridge The University of Cambridge is a public collegiate research university in Cambridge, England. Founded in 1209 and granted a royal charter by Henry III in 1231, Cambridge is the world's third oldest surviving university and one of its most pr ...

in 2003, the

University of Kent , motto_lang = , mottoeng = Literal translation: 'Whom to serve is to reign'(Book of Common Prayer translation: 'whose service is perfect freedom')Graham Martin, ''From Vision to Reality: the Making of the University of Kent at Canterbury'' ...

in 2012, the

University of Warwick , mottoeng = Mind moves matter , established = , type = Public research university , endowment = £7.0 million (2021) , budget = £698.2 million (2020� ...

(Doctor of Science) the

University of Worcester , motto_lang = la , mottoeng = ''Aspire to Inspire'' , established = 1946 – Worcester Emergency Teacher Training College 1948 – Worcester Teacher Training College 1976 – Worcester College of Higher Education 1997 – ...

(Doctor of Science) in 2013,

City, University of London City, University of London, is a public research university in London, United Kingdom, and a member institution of the federal University of London. It was founded in 1894 as the Northampton Institute, and became a university when The City Univ ...

(Doctor of Science) in 2014 and

McGill University McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec Montreal ( ; officially Montréal, ) is the second-most populous city in Canada and most populous ...

(Doctor of Science) in 2017. In 2020 he was awarded an honorary degree from the

Mendel University Brno Mendel University in Brno is located in Brno, Czech Republic. It was founded on 24 July 1919 on the basis of the former Tábor Academy. It now consists of five faculties and one institute - the Faculty of AgriSciences, Faculty of Forestry and W ...

in the Czech Republic. He was also appointed an Honorary Fellow of the Royal Academy of Engineering (HonFREng) in 2012 and Honorary Fellow of the British Association (HonFBA) in 2013. In July 2016 it was announced that he will be the next Chancellor of the

University of Bristol , mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type ...

. He is an Honorary Liveryman of the Worshipful Company of Scientific Instrument Makers.

Personal life

Nurse married Anne Teresa (née Talbott) in 1971; they have two daughters – Sarah, who works for ITV, and Emily,Emily Nurse's a physicist based at

University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...

and CERN. He describes himself as a sceptical agnostic.

Political views

Nurse has been a member of the

Labour Party (UK) The Labour Party is a political party in the United Kingdom that has been described as an alliance of social democrats, democratic socialists and trade unionists. The Labour Party sits on the centre-left of the political spectrum. In all gen ...

for nearly 40 years and is a patron of

Scientists for Labour Scientists for Labour is a socialist society affiliated to the British Labour Party. It is open to supporters of the Labour Party interested or involved in UK science and technology. Notable patrons include the Nobel Prize winning geneticist, ...

, a Socialist Society affiliated to the Labour Party. In September 2020, he was a co-author on a letter in ''

Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are ...

'' alongside former Prime Minister

Gordon Brown James Gordon Brown (born 20 February 1951) is a British former politician who served as Prime Minister of the United Kingdom and Leader of the Labour Party from 2007 to 2010. He previously served as Chancellor of the Exchequer in Tony B ...

highlighting the importance of EU funding in the fight against

COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quickly ...

. As an undergraduate student at Birmingham, Nurse sold ''

Socialist Worker ''Socialist Worker'' is the name of several far-left newspapers currently or formerly associated with the International Socialist Tendency (IST). It is a weekly newspaper published by the Socialist Workers Party (SWP) in the United Kingdom since ...

'', and participated in an occupation of the vice-chancellor's office. As a graduate student at East Anglia he continued to sell ''Socialist Worker'', and was sympathetic to the

International Socialist Tendency The International Socialist Tendency (IST) is an international grouping of unorthodox Trotskyist organisations espousing the ideas of Tony Cliff (1917–2000), founder of the Socialist Workers Party (SWP) in Britain (not to be confused with ...

but never formally joined the movement. Nurse has criticized potential Republican Party candidates for the US presidential nomination for opposing the teaching of

natural selection Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations. Cha ...

, stem cell research on cell lines from human embryos, and anthropogenic climate change, even partially blaming scientists for not speaking up.Stamp out anti-science; it's time to reject political movements that turn their backs on science
Paul Nurse, New Scientist, 17 September 2011 He was alarmed that this could happen in the U.S., a world leader in science, "the home of

Benjamin Franklin Benjamin Franklin ( April 17, 1790) was an American polymath who was active as a writer, scientist, inventor, statesman, diplomat, printer, publisher, and political philosopher. Encyclopædia Britannica, Wood, 2021 Among the leading inte ...

Richard Feynman Richard Phillips Feynman (; May 11, 1918 – February 15, 1988) was an American theoretical physicist, known for his work in the path integral formulation of quantum mechanics, the theory of quantum electrodynamics, the physics of the superfl ...

and Jim Watson." One problem, Nurse said, was "treating scientific discussion as if it were political debate," using rhetorical tricks rather than logic. Another was the state of science teaching in the schools, which does not teach citizens how to discuss science – particularly in religious schools, even in the United Kingdom. Nurse has written that "we need to emphasise why the scientific process is such a reliable generator of knowledge with its respect for evidence, for scepticism, for consistency of approach, for the constant testing of ideas." Furthermore, Nurse feels that scientific leaders "have a responsibility to expose the bunkum". They should take on politicians, and expose nonsense during elections. In August 2014, Nurse was one of 200 public figures who were signatories to a letter to ''

The Guardian ''The Guardian'' is a British daily newspaper. It was founded in 1821 as ''The Manchester Guardian'', and changed its name in 1959. Along with its sister papers ''The Observer'' and ''The Guardian Weekly'', ''The Guardian'' is part of the Gu ...

'' expressing their hope that Scotland would vote to remain part of the United Kingdom in September's referendum on that issue. Nurse believes that scientists should speak out about science in public affairs and challenge politicians who support policies based on

pseudoscience Pseudoscience consists of statements, beliefs, or practices that claim to be both scientific and factual but are incompatible with the scientific method. Pseudoscience is often characterized by contradictory, exaggerated or unfalsifiable clai ...

References

External links

* including the Nobel Lecture Nobel Lecture 9 December 2001 ''Controlling the Cell Cycle''
Stories told by Paul Nurse
at

The Moth The Moth is a non-profit group based in New York City dedicated to the art and craft of storytelling. Founded in 1997, the organization presents a wide range of theme-based storytelling events across the United States and abroad, often featuring ...

Paul Nurse on the premiere episode of ''The Life Scientific''
(

BBC Radio 4 BBC Radio 4 is a British national radio station owned and operated by the BBC that replaced the BBC Home Service in 1967. It broadcasts a wide variety of spoken-word programmes, including news, drama, comedy, science and history from the BBC' ...

), originally aired: 11 Oct 2011, 30 minutes in length {{DEFAULTSORT:Nurse, Paul 1949 births Living people Academics of the Francis Crick Institute Academics of the University of Edinburgh Academics of the University of Oxford Albert Einstein World Award of Science Laureates Alumni of the University of Birmingham Alumni of the University of East Anglia British biochemists British geneticists British Nobel laureates Cell biologists English agnostics English Nobel laureates Fellows of Churchill College, Cambridge Fellows of the Royal Society Foreign associates of the National Academy of Sciences Foreign members of the Chinese Academy of Sciences Knights Bachelor Members of the European Molecular Biology Organization Members of the Order of Merit Members of the Order of the Companions of Honour Nobel laureates in Physiology or Medicine People educated at Harrow High School Scientists from Norwich Presidents of Rockefeller University Presidents of the Royal Society Recipients of the Albert Lasker Award for Basic Medical Research Recipients of the Copley Medal Royal Medal winners Winners of the Heineken Prize Honorary Fellows of the British Academy Fellows of the Academy of Medical Sciences (United Kingdom)