Setiptiline (brand name Tecipul), also known as teciptiline, is a
tetracyclic antidepressant
Tetracyclic antidepressants (TeCAs) are a class of antidepressants that were first introduced in the 1970s. They are named after their tetracyclic chemical structure, containing four rings of atoms, and are closely related to the tricyclic ant ...
(TeCA) that acts as a
noradrenergic and specific serotonergic antidepressant
Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. They act by antagonizing the α2-adrenergic receptor and certain serotonin receptors such as 5-HT2A and 5-HT2 ...
(NaSSA). It was launched in 1989 for the treatment of
depression in
Japan by
Mochida.
Pharmacology
Pharmacodynamics
Setiptiline acts as a
norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epin ...
,
,
and
serotonin receptor antagonist,
likely at the
5-HT2 subtypes, as well as an
H1 receptor inverse agonist/
antihistamine
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provid ...
.
[
]
Chemistry
Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine
Mirtazapine, sold under the brand name Remeron amongst others, is an Atypical antidepressant, atypical antidepressant, and as such is used primarily to treat Depression (mood), depression. Its effects may take up to four weeks, but can also man ...
, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-azamianserin.
See also
* Aptazapine
* Mianserin
* Mirtazapine
Mirtazapine, sold under the brand name Remeron amongst others, is an Atypical antidepressant, atypical antidepressant, and as such is used primarily to treat Depression (mood), depression. Its effects may take up to four weeks, but can also man ...
References
Alpha-2 blockers
H1 receptor antagonists
Noradrenergic and specific serotonergic antidepressants
Piperidines
Serotonin receptor antagonists
Tetracyclic antidepressants
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