Serinolamide A is a naturally occurring
eicosanoid
Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, around 20 carbon units in length. Eicosanoids are a s ...
derivative related to
anandamide
Anandamide (ANA), also known as ''N''-arachidonoylethanolamine (AEA), is a fatty acid neurotransmitter. Anandamide was the first endocannabinoid to be discovered: it participates in the body's endocannabinoid system by binding to cannabinoid r ...
, which has been isolated from the marine
cyanobacteria ''
Lyngbya majuscula'' and related
species
In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...
in the ''
Oscillatoria
''Oscillatoria'' is a genus of filamentous cyanobacterium which is often found in freshwater environments, such as hot springs, and appears blue-green. Its name refers to the oscillating motion of its filaments as they slide against each other ...
'' family.
Testing established that serinolamide A is an active
cannabinoid
Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...
agonist with moderate potency, having a K
i of 1300 nM at CB
1 and five fold selectivity over the related CB
2 receptor.
See also
*
Methanandamide
*
O-1812
O-1812 is an eicosanoid derivative related to anandamide that acts as a potent and highly selective agonist for the cannabinoid receptor CB1, with a ''K''i of 3.4 nM at CB1 and 3870 nM at CB2. Unlike most related compounds, O-1812 i ...
*
Perrottetinene
References
External links
What Is CBG Oil?CBD Oil For Pain
Cannabinoids
Fatty acid amides
{{cannabinoid-stub