A selective androgen receptor degrader or downregulator (SARD) is a type of
drug which interacts with the
androgen receptor (AR) such that it causes the AR to be degraded and thus
downregulated
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus. The complementary proc ...
.
They are under investigation for the treatment of
prostate cancer and other
androgen-dependent condition An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body.
Known androgen-dependent conditions include acne, ...
s.
As of 2017,
dimethylcurcumin
Dimethylcurcumin (development code ASC-J9) is a nonsteroidal antiandrogen and a synthetic curcuminoid which is under development by AndroScience Corporation as a topical medication for the treatment of acne vulgaris. It has also been under inve ...
(ASC-J9), a SARD, is under development for the treatment of
acne vulgaris.
See also
*
Androgen deprivation therapy
Androgen deprivation therapy (ADT), also called androgen suppression therapy, is an antihormone therapy whose main use is in treating prostate cancer. Prostate cancer cells usually require androgen hormones, such as testosterone, to grow. ADT red ...
References
Antiandrogens
Hormonal antineoplastic drugs
{{Antineoplastic-drug-stub