Sauvagine is a

neuropeptide Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...

from the

corticotropin-releasing factor Corticotropin-releasing factor family, CRF family is a family of related neuropeptides in vertebrates. This family includes corticotropin-releasing hormone (also known as CRF), urotensin-I, urocortin, and sauvagine. The family can be grouped int ...

(CRF) family of peptides and is

orthologous Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a spec ...

to the mammalian hormone, urocortin 1, and the

teleost Teleostei (; Greek ''teleios'' "complete" + ''osteon'' "bone"), members of which are known as teleosts ), is, by far, the largest infraclass in the class Actinopterygii, the ray-finned fishes, containing 96% of all extant species of fish. Tel ...

fish hormone, urotensin 1. It is 40 amino acids in length, and has the sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog ''

Phyllomedusa sauvagii ''Phyllomedusa sauvagii'', the waxy monkey leaf frog or waxy monkey tree frog, is a species of frog in the subfamily Phyllomedusinae. It is native to South America, where it occurs in Argentina, Bolivia, Paraguay and Brazil. This species is arbor ...

.'' Given its relation to other CRF-related peptides, it exerts similar physiological effects as

corticotropin-releasing hormone Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress (biology), stress responses. It is a releasing ...

. Sauvagine belongs to the

(CRF) family that also includes CRF, urocortin l/urotensin l,

urocortin II Urocortin 2 (Ucn2) is an endogenous peptide in the corticotrophin-releasing factor (CRF) family. Urocortin II is a 38-amino acid peptide that is a member of the CRF family of peptides. Unlike Urocortin I, Urocortin II is highly selective for th ...

and

urocortin III Urocortin III is a 38 amino acid peptide that is a member of the CRF family of peptides. Unlike Urocortin I, and similar to Urocortin II, Urocortin III is highly selective for the CRF2 receptor and does not show affinity for the CRF binding prot ...

Interactions

Sauvagine has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with corticotropin releasing factor receptors 1 and 2, and (as with other CRF-related peptides) is also bound by the corticotropin-releasing factor binding protein.

References

Corticotropin-releasing hormone receptor agonists Peptide hormones {{biochem-stub