Sappinia amoebic encephalitis (SAE) is the name for amoebic encephalitis caused by species of Sappinia.[1]

The causative organism was originally identified as Sappinia diploidea,[2][3] but is now considered to be Sappinia pedata.[4]

It has been treated with azithromycin, pentamidine, itraconazole, and flucytosine.[3]


  1. ^ Da Rocha-Azevedo, B.; Tanowitz, H.; Marciano-Cabral, F. (2009). "Diagnosis of infections caused by pathogenic free-living amoebae". Interdisciplinary perspectives on infectious diseases. 2009: 251406. doi:10.1155/2009/251406. PMC 2719787Freely accessible. PMID 19657454. 
  2. ^ Gelman, B. B.; Rauf, S. J.; Nader, R.; Popov, V.; Borkowski, J.; Chaljub, G.; Nauta, H. W.; Visvesvara, G. S. (2001). "Amoebic encephalitis due to Sappinia diploidea". JAMA: the Journal of the American Medical Association. 285 (19): 2450–2451. doi:10.1001/jama.285.19.2450. PMID 11368696. 
  3. ^ a b Gelman, B. B.; Popov, V.; Chaljub, G.; Nader, R.; Rauf, S. J.; Nauta, H. W.; Visvesvara, G. S. (2003). "Neuropathological and ultrastructural features of amebic encephalitis caused by Sappinia diploidea". Journal of neuropathology and experimental neurology. 62 (10): 990–998. PMID 14575235. 
  4. ^ Qvarnstrom, Y.; Da Silva, A.; Schuster, F.; Gelman, B.; Visvesvara, G. (2009). "Molecular confirmation of Sappinia pedata as a causative agent of amoebic encephalitis". The Journal of Infectious Diseases. 199 (8): 1139–1142. doi:10.1086/597473. PMID 19302010.