Sakuranetin is a flavan-on, the 7-methoxy derivative of naringenin, found in Polymnia fruticosa and rice, where it acts as a

phytoalexin Phytoalexins are antimicrobial substances, some of which are antioxidative as well. They are defined, not by their having any particular chemical structure or character, but by the fact that they are defensively synthesized ''de novo'' by plants th ...

against spore germination of '' Pyricularia oryzae''.

Glycosides

Sakuranin is the 5-O- glucoside of sakuranetin.

Metabolism

; biosynthesis Naringenin 7-O-methyltransferase uses

naringenin Naringenin is a flavorless, colorless flavanone, a type of flavonoid. It is the predominant flavanone in grapefruit, and is found in a variety of fruits and herbs. Structure Naringenin has the skeleton structure of a flavanone with three hydro ...

to yield sakuranetin, with S-adenosyl-methionine as the methyl donor. ; biodegradation In compounds like 7-methoxylated flavanones like sakuranetin,

demethylation Demethylation is the chemical process resulting in the removal of a methyl group (CH3) from a molecule. A common way of demethylation is the replacement of a methyl group by a hydrogen atom, resulting in a net loss of one carbon and two hydrogen at ...

followed by

sulfation Sulfation is the chemical reaction that entails the addition of SO3 group. In principle, many sulfations would involve reactions of sulfur trioxide (SO3). In practice, most sulfations are effected less directly. Regardless of the mechanism, the ...

occur in model organism '' Cunninghamella elegans''.

References

Aromatase inhibitors O-methylated flavanones Phytoalexins {{aromatic-stub