RefSeq (protein)



Location (UCSC) Chr 17: 47.9 – 47.93 Mb Chr 11: 96.95 – 96.98 Mb PubMed search [3] [4] Wikidata
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Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.[5][6][7]


This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.[7]


Sp2 transcription factor has been shown to interact with E2F1.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167182 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018678 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kingsley C, Winoto A (Oct 1992). "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression". Mol Cell Biol. 12 (10): 4251–61. PMC 360348Freely accessible. PMID 1341900. 
  6. ^ Scohy S, Van Vooren P, Szpirer C, Szpirer J (Oct 1998). "Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization". Cytogenet Cell Genet. 81 (3–4): 273–4. doi:10.1159/000015044. PMID 9730617. 
  7. ^ a b "Entrez Gene: SP2 Sp2 transcription factor". 
  8. ^ Rotheneder H, Geymayer S, Haidweger E (Nov 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281. 

Further reading

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