SCH-442,416 is a highly selective
adenosine A2a subtype receptor
antagonist. It is widely used in its
11C
radiolabelled
Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation in neutron count) through a reaction, metabolic pathway, or cell. The reactant is 'labeled' by replacing specific ...
form to map the distribution of A
2a receptors in the brain, where they are mainly found in the
striatum,
nucleus accumbens
The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the ''nucleus accumbens septi'', Latin for " nucleus adjacent to the septum") is a region in the basal forebrain rostral to the preoptic area of the hypot ...
, and
olfactory tubercle
The olfactory tubercle (OT), also known as the tuberculum olfactorium, is a multi-sensory processing center that is contained within the olfactory cortex and ventral striatum and plays a role in reward cognition. The OT has also been shown to ...
. Given its distribution in the brain, A
2a receptors have been investigated for the treatment of various neurological disorders, and SCH-442,416 has shown promise in treatment of
depression,
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...
, and
catalepsy
Catalepsy (from Ancient Greek , , "seizing, grasping") is a nervous condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain.
Signs and symptoms
Symptoms in ...
.
References
External links
Molecular Imaging and Contrast Agent Database: SCH-442,416
Phenol ethers
2-Furyl compounds
Adenosine receptor antagonists
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