SB-612,111 is an
opioid receptor ligand which is a potent and selective antagonist for the
nociceptin receptor (ORL-1), several times more potent than the older drug J-113,397. It does not have
analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
effects in its own right, but prevents the development of
hyperalgesia, and also shows
antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, hea ...
effects in animal studies.
See also
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JTC-801
JTC-801 is an opioid analgesic drug used in scientific research.
JTC-801 is a selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. This was the fourth opioid receptor to be discovered and is still the least unders ...
*
J-113,397
J-113,397 is an opioid drug which was the first compound found to be a highly selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. It is several hundred times selective for the ORL-1 receptor over other opioid rece ...
*
LY-2940094
BTRX-246040, also known as LY-2940094, is a potent and selective nociceptin receptor antagonist which is under development by BlackThorn Therapeutics and Eli Lilly for the treatment of major depressive disorder (MDD). It has demonstrated proof ...
References
4-Phenylpiperidines
Opioids
Chloroarenes
Secondary alcohols
Nociceptin receptor antagonists
{{Analgesic-stub