SB-258585 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

antagonist, with a Ki of 8.9nM. It is used in its ¹²⁵I

radiolabelled Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation in neutron count) through a reaction, metabolic pathway, or cell. The reactant is 'labeled' by replacing specific ...

form to map the distribution of 5-HT₆ receptors in the brain. SB-258585 and other 5-HT₆ antagonists show

nootropic Nootropics ( , or ) (colloquial: smart drugs and cognitive enhancers, similar to adaptogens) are a wide range of natural or synthetic dietary supplement, supplements or drugs and other substances that are claimed to improve cognitive function ...

effects in animal studies, as well as antidepressant and

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

effects, and have been proposed as potential novel treatments for cognitive disorders such as

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social wit ...

and Alzheimer's disease.

References

5-HT6 antagonists N-(2-methoxyphenyl)piperazines Sulfonamides Iodoarenes {{nervous-system-drug-stub