Ryanoids are a class of
insecticides which share the same
mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targ ...
as the
alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
ryanodine
Ryanodine is a poisonous diterpenoid found in the South American plant ''Ryania speciosa'' (Salicaceae). It was originally used as an insecticide.
The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium cha ...
. Ryanodine is a naturally occurring insecticide isolated from ''
Ryania speciosa''.
Ryanoids include natural chemicals which are closely related to ryanodine, such as
ryanodol and
9,21-didehydroryanodol, and also chemically distinct synthetic compounds such as
chlorantraniliprole (Rynaxypyr),
flubendiamide,
cyantraniliprole,
cyclaniliprole, and
tetraniliprole, which are called diamide insecticides.
Ryanoids exert their insecticidal effect by interacting with
ryanodine receptors, a type of
calcium channel. This causes loss of muscle function
leading to paralysis and death.
References
{{insecticides
Insecticides