Roger J. Williams
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Roger John Williams (August 14, 1893 – February 20, 1988), was an American
biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological ch ...
. He is known for is work on vitamins and human nutrition. He had leading roles in the discovery of
folic acid Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing a ...
,
pantothenic acid Pantothenic acid, also called vitamin B5 is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to, ...
,
vitamin B6 Vitamin B6 is one of the B vitamins, and thus an essential nutrient. The term refers to a group of six chemically similar compounds, i.e., " vitamers", which can be interconverted in biological systems. Its active form, pyridoxal 5′-phosp ...
,
lipoic acid Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA is made in animals normally, and is essential for aerobic metabolism. It i ...
, and
avidin Avidin is a tetrameric biotin-binding protein produced in the oviducts of birds, reptiles and amphibians and deposited in the whites of their eggs. Dimeric members of the avidin family are also found in some bacteria. In chicken egg white, avid ...
. He was elected to the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...
in 1946, and served as the president of the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all ...
in 1957. In his later career he spent time writing for a popular audience on the importance of
nutrition Nutrition is the biochemical and physiological process by which an organism uses food to support its life. It provides organisms with nutrients, which can be metabolized to create energy and chemical structures. Failure to obtain sufficient ...
.


Early life and education

Roger John Williams was born in
Ootacamund Ooty (), officially known as Udhagamandalam (also known as Ootacamund (); abbreviated as Udhagai), is a city and a municipality in the Nilgiris district of the South Indian state of Tamil Nadu. It is located north west of Coimbatore and ...
,
India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the List of countries and dependencies by area, seventh-largest country by area, the List of countries and dependencies by population, second-most populous ...
of American parents on August 14, 1893. His family returned to the US when he was two years old, and he grew up in Kansas and California. He attributed his early interest in chemistry to the influence of his brother Robert R. Williams, eight years his senior, who was also a chemist. Robert is remembered for being the first to synthesize
thiamine Thiamine, also known as thiamin and vitamin B1, is a vitamin, an essential micronutrient, that cannot be made in the body. It is found in food and commercially synthesized to be a dietary supplement or medication. Phosphorylated forms of thi ...
(vitamin B1). Roger was an undergraduate at the
University of Redlands The University of Redlands is a private university headquartered in Redlands, California. The university's main, residential campus is situated on 160 acres (65 ha) near downtown Redlands. An additional eight regional locations throughout Califo ...
and received his bachelor's degree in 1914. He received a teaching certificate from the
University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant un ...
the following year and began work as a science teacher in California. After a year of teaching, he decided to return to school and began graduate work at the
University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...
, from which he received his Ph.D. in 1919. His Ph.D Thesis was entitled ''The Vitamine Requirements of Yeasts''.Biography
Roger J. Williams: Nutrition Scientist
at the website PAULING BLOG. It says William's Ph.D Thesis title was in the spelling ''The Vitamin Requirement of Yeast''.
Julius Stieglitz Julius Oscar Stieglitz (May 26, 1867 – January 10, 1937) was an American chemist of German Jewish origin. He was a teacher and organic chemist with a major interest in pharmaceutical and medicinal chemistry. He is known for the Stieglitz rearran ...
was the chairman of the department of chemistry at U Chicago when Roger Williams was a student there, and Williams later described Stieglitz as a major influence upon him in
organic chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J ...
.


Academic career

Williams began his academic research career by joining the faculty at the
University of Oregon The University of Oregon (UO, U of O or Oregon) is a public research university in Eugene, Oregon. Founded in 1876, the institution is well known for its strong ties to the sports apparel and marketing firm Nike, Inc Nike, Inc. ( or ) is a ...
in 1920. During the following twelve years he spent there, he discovered
pantothenic acid Pantothenic acid, also called vitamin B5 is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to, ...
. In 1932 he moved to
Oregon State College Oregon State University (OSU) is a public land-grant, research university in Corvallis, Oregon. OSU offers more than 200 undergraduate-degree programs along with a variety of graduate and doctoral degrees. It has the 10th largest engineering ...
and in 1939 he moved again to the
University of Texas at Austin The University of Texas at Austin (UT Austin, UT, or Texas) is a public research university in Austin, Texas. It was founded in 1883 and is the oldest institution in the University of Texas System. With 40,916 undergraduate students, 11,075 ...
. He founded and became the founding director of the Biochemical Institute (later the Clayton Foundation Biochemical Institute) in 1940 with funding from Benjamin Clayton. Williams' research program was notable in that he used
yeast Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom. The first yeast originated hundreds of millions of years ago, and at least 1,500 species are currently recognized. They are estimated to constit ...
as
model organism A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...
s to study nutritional requirements, on the hypothesis that the underlying cellular biochemistry was generalizable from yeast to animals. He aimed to study
vitamin A vitamin is an organic molecule (or a set of molecules closely related chemically, i.e. vitamers) that is an essential micronutrient that an organism needs in small quantities for the proper functioning of its metabolism. Essential nutrie ...
s, at the time known as animal nutrients whose chemical properties were not characterized. This approach was successful in leading to the discovery of
pantothenic acid Pantothenic acid, also called vitamin B5 is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to, ...
, published in 1933, which prompted renewed interest among biochemists in microbial metabolism. Williams and his colleagues in Texas – including Robert Eakin, Beverly Guirard, Esmond Snell, William Shive, and Lester Reed – continued this work and used the technique to discover a number of other vitamins and nutrients. Williams and Snell, along with student
Herschel K. Mitchell Herschel Kenworthy Mitchell (November 27, 1913 – April 1, 2000) was an American professor of biochemistry who spent most of his career on the faculty at the California Institute of Technology. He was one of many researchers interested in vit ...
, isolated and named
folic acid Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing a ...
by extracting it from four tons of processed
spinach Spinach (''Spinacia oleracea'') is a leafy green flowering plant native to central and western Asia. It is of the order Caryophyllales, family Amaranthaceae, subfamily Chenopodioideae. Its leaves are a common edible vegetable consumed either f ...
. He also worked on discovering and isolating
vitamin B6 Vitamin B6 is one of the B vitamins, and thus an essential nutrient. The term refers to a group of six chemically similar compounds, i.e., " vitamers", which can be interconverted in biological systems. Its active form, pyridoxal 5′-phosp ...
,
lipoic acid Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA is made in animals normally, and is essential for aerobic metabolism. It i ...
, and
avidin Avidin is a tetrameric biotin-binding protein produced in the oviducts of birds, reptiles and amphibians and deposited in the whites of their eggs. Dimeric members of the avidin family are also found in some bacteria. In chicken egg white, avid ...
. Throughout his career Williams was a prolific writer, producing not only hundreds of scientific papers but also a number of widely used textbooks. Williams retired from his role at the director of the Biochemical Institute in 1963 and from the University of Texas in 1986.


Nutrition Educator

Roger Williams devoted much of his later years to educating the public about the benefits of complete and proper nutrition to good health. This consisted chiefly of him writing popular books about nutrition. One of Williams's popular books is entitled ''Biochemical Individuality''. In it, Williams emphasized the uniqueness of each person in their metabolic makeup and micronutrient needs. Because of "biochemical individuality", nutritional requirements are not fully the same for everybody.


Awards and honors

* Elected to the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...
, 1946 * President of the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all ...
, 1957 * Fellow of the
American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...


Personal life

Williams married his high school sweetheart Hazel Elizabeth Wood in 1916 during his stint teaching in California. The couple had three children. After Hazel died in 1952, he married Mabel Phyllis Hobson; the two enjoyed extensive travel. Williams also enjoyed fishing and golf and played the violin and piano. For most of his life Williams suffered from eyestrain caused by
aniseikonia Aniseikonia is an ocular condition where there is a significant difference in the perceived size of images. It can occur as an overall difference between the two eyes, or as a difference in a particular meridian. If the ocular image size in both e ...
, a condition that was not recognized during his youth; he had glasses specially made to treat the condition in the 40s. Williams died on February 20, 1988. His wife Phyllis survived him and died in 2004.


Books

* ''The Human Frontier'' (Harcourt Brace, 1946) * ''The Biochemistry of B vitamins'', Roger J. Williams and others (Reinhold Pub. Corp., 1950) * ''Nutrition and Alcoholism'', Roger J. Williams (Univ. of Oklahoma Press, 1951) * ''Free and Unequal: The Biological Basis of Individual Liberty.'' (Univ. of Texas Press, 1953) * ''Biochemical Individuality: The Basis for the Genetotrophic Concept'' (John Wiley & Sons, 1956; University of Texas Press, 1969 to 1979; Keats Publishing, 1998, ) (also translated into Russian, Italian and Polish) * ''Alcoholism: The Nutritional Approach'' (Univ. of Texas Press, 1959 to 1978) * ''Nutrition in a Nutshell'' (1962, Doubleday and Dolphin) * ''The Encyclopedia of Biochemistry'', edited by Roger J. Williams and Edwin M. Lansford, Jr. (Reinhold Pub. Corp., 1967) * ''You are Extraordinary'' (Random House, 1967) * ''Nutrition Against Disease: Environmental Prevention'' (Pitman 1971, Bantam Books, 1973) * ''Physicians' Handbook of Nutritional Science'' (C.C. Thomas, 1975) * ''The Wonderful World Within You: Your Inner Nutritional Environment'' (Bantam Books, 1977; Bio-Communications Press 1987–1998) * ''The Prevention of Alcoholism Through Nutrition'' (Bantam Books, 1981) * ''Rethinking Education: The Coming Age of Enlightenment'' (Philosophical Library, 1986).


References


External links


A compilation of Williams' writings
maintained by Donald R. Davis * {{DEFAULTSORT:Williams, Roger J. 1893 births 1988 deaths American expatriates in British India American health and wellness writers American nutritionists Oregon State University faculty University of Oregon faculty University of Texas at Austin faculty Deaths from pneumonia in Texas Dietitians Members of the United States National Academy of Sciences Vitamin researchers