Rnd1 is a small (~21 kDa) signaling

G protein G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their a ...

(to be specific, a

GTPase GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a pro ...

), and is a member of the Rnd subgroup of the

Rho family of GTPases The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are foun ...

. It is encoded by the gene RND1. It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998). upplied by OMIMref name="entrez" />

Interactions

Rnd1 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

GRB7 Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the ''GRB7'' gene. Function The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number ...

PLXNB1 Plexin B1 is a protein of the plexin family that in humans is encoded by the ''PLXNB1'' gene. Function Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins. Outside of neural tissues, Plexin B1 is implic ...

PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the ''PDE6D'' gene. PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) ...

ARHGAP5 Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ''ARHGAP5'' gene. Function Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrol ...

and UBXD5.

Interactions

References

Further reading