Ribonucleotide reductase inhibitors are a family of
anti-cancer drugs that interfere with the growth of
tumor cells
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...
by blocking the formation of
deoxyribonucleotides (building blocks of
DNA).
Examples include:
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motexafin gadolinium.
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hydroxyurea
Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. In sickle-cell disease it increases fetal hemoglobin and d ...
*
fludarabine,
cladribine
Cladribine, sold under the brand name Leustatin, among others, is a medication used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and B-cell chronic lymphocytic leukemia.
Cladribine, sold under the brand name Mavenclad, is indicat ...
,
gemcitabine
Gemcitabine, with brand names including Gemzar, is a chemotherapy medication. It treats cancers including testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer, and bladder cancer. It is administered by ...
,
tezacitabine, and
triapine
3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, also called Triapine) is a substance that is being studied in the treatment of cancer.
It belongs to the family of drugs called ribonucleotide reductase inhibitors.
3AP is a potent inhib ...
*
gallium maltolate,
gallium nitrate
Gallium nitrate (brand name Ganite) is the gallium Salt (chemistry), salt of nitric acid with the chemical formula Ga(NO3)3. It is a drug used to treat symptomatic hypercalcemia secondary to cancer. It works by preventing the breakdown of bone thr ...
See also
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Ribonucleotide reductase
References
External links
Ribonucleotide reductase inhibitorentry in the public domain NCI Dictionary of Cancer Terms
Antineoplastic drugs
Oxidoreductase inhibitors
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