Ribonucleoside-triphosphate reductase (, ''
ribonucleotide reductase'', ''2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H
2O
ribonucleoside triphosphate +
thioredoxin
Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by ''TXN'' and '' TXN2'' genes. Loss-of-fu ...
Ribonucleoside-triphosphate reductase requires a
cobamide coenzyme
A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases the rate of a chemical reaction). Cofactors can be considered "helper molecules" that ass ...
and
ATP.
References
External links
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EC 1.17.4