RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling
G protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their a ...
(more specifically a
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a pro ...
), and is a member of the
Rac subfamily of the family
Rho family of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are foun ...
.
It is encoded by the gene RHOD.
It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.
Interactions
RhoD has been shown to
interact with
CNKSR1
Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the ''CNKSR1'' gene.
Function
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It ...
and
DIAPH2.
References
Further reading
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