A retrospective diagnosis (also retrodiagnosis or posthumous diagnosis) is the practice of identifying an illness after the death of the patient (sometimes in a historical figure) using modern knowledge, methods and disease classifications. Alternatively, it can be the more general attempt to give a modern name to an ancient and ill-defined scourge or plague.

Historical research

Retrospective diagnosis is practised by medical historians, general historians and the media with varying degrees of scholarship. At its worst it may become "little more than a game, with ill-defined rules and little academic credibility". The process often requires "translating between linguistic and conceptual worlds separated by several centuries", and assumes our modern disease concepts and categories are privileged. Crude attempts at retrospective diagnosis fail to be sensitive to historical context, may treat historical and religious records as scientific evidence, or ascribe pathology to behaviours that require none.Getz, Faye M. Western Medieval Medicine in Darin Hayton, a

historian of science The history of science covers the development of science from ancient times to the present. It encompasses all three major branches of science: natural, social, and formal. Science's earliest roots can be traced to Ancient Egypt and Mesopo ...

at Haverford College, claims that retrodiagnosing famous individuals with autism in the media is pointless, as historical accounts often contain incomplete information. The understanding of the history of illness can benefit from modern science. For example, knowledge of the insect vectors of

malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...

and

yellow fever Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. ...

can be used to explain the changes in extent of those diseases caused by drainage or urbanisation in historical times. The practice of retrospective diagnosis has been applied in

parody A parody, also known as a spoof, a satire, a send-up, a take-off, a lampoon, a play on (something), or a caricature, is a creative work designed to imitate, comment on, and/or mock its subject by means of satiric or ironic imitation. Often its sub ...

, where characters from fiction are "diagnosed".

Squirrel Nutkin ''The Tale of Squirrel Nutkin'' is a children's book written and illustrated by Beatrix Potter and first published by Frederick Warne & Co. in August 1903. The story is about an impertinent red squirrel named Nutkin and his narrow escape from ...

may have had

Tourette syndrome Tourette syndrome or Tourette's syndrome (abbreviated as TS or Tourette's) is a common neurodevelopmental disorder that begins in childhood or adolescence. It is characterized by multiple movement (motor) tics and at least one vocal (phonic) ...

and Tiny Tim could have had distal renal tubular acidosis (type I).

Postmortem diagnosis

Post-mortem diagnosis is considered a research tool, and also a quality control practice and it allows to evaluate the performance of the

clinical case definition In epidemiology, a clinical case definition, a clinical definition, or simply a case definition lists the clinical criteria by which public health professionals determine whether a person's illness is included as a ''case'' in an outbreak investi ...

s. The term ''retrospective diagnosis'' is also sometimes used by a

clinical pathologist Clinical pathology is a medical specialty that is concerned with the diagnosis of disease based on the Medical laboratory, laboratory analysis of bodily fluids, such as blood, urine, and tissue homogenates or extracts using the tools of clinic ...

to describe a

medical diagnosis Medical diagnosis (abbreviated Dx, Dx, or Ds) is the process of determining which disease or condition explains a person's symptoms and signs. It is most often referred to as diagnosis with the medical context being implicit. The information r ...

in a person made some time after the original illness has resolved or after death. In such cases, analysis of a physical specimen may yield a confident medical diagnosis. The search for the origin of AIDS has involved posthumous diagnosis of AIDS in people who died decades before the disease was first identified. Another example is where analysis of preserved

umbilical cord In placental mammals, the umbilical cord (also called the navel string, birth cord or ''funiculus umbilicalis'') is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologi ...

tissue enables the diagnosis of congenital cytomegalovirus infection in a patient who had later developed a

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...

disorder.

Examples

* Did

Abraham Abraham, ; ar, , , name=, group= (originally Abram) is the common Hebrew patriarch of the Abrahamic religions, including Judaism, Christianity, and Islam. In Judaism, he is the founding father of the special relationship between the Je ...

, Moses,

Jesus Jesus, likely from he, יֵשׁוּעַ, translit=Yēšūaʿ, label= Hebrew/ Aramaic ( AD 30 or 33), also referred to as Jesus Christ or Jesus of Nazareth (among other names and titles), was a first-century Jewish preacher and religiou ...

Saint Paul Paul; grc, Παῦλος, translit=Paulos; cop, ⲡⲁⲩⲗⲟⲥ; hbo, פאולוס השליח (previously called Saul of Tarsus;; ar, بولس الطرسوسي; grc, Σαῦλος Ταρσεύς, Saũlos Tarseús; tr, Tarsuslu Pavlus; ...

have psychotic spectrum psychological symptoms? * Did

Tutankhamun Tutankhamun (, egy, twt-ꜥnḫ-jmn), Egyptological pronunciation Tutankhamen () (), sometimes referred to as King Tut, was an Egyptian pharaoh who was the last of his royal family to rule during the end of the Eighteenth Dynasty (ruled ...

have

Klippel–Feil syndrome Klippel–Feil syndrome (KFS), also known as cervical vertebral fusion syndrome, is a rare congenital condition characterized by the abnormal fusion of any two of the seven bones in the neck (cervical vertebrae). It results in a limited ability ...

? * Did Alfred the Great have Crohn's disease? * Did

botulism Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium ''Clostridium botulinum''. The disease begins with weakness, blurred vision, feeling tired, and trouble speaking. This may then be followed by weakne ...

cause the religious visions experienced by Julian of Norwich? * Was the

English sweat Sweating sickness, also known as the sweats, English sweating sickness, English sweat or ''sudor anglicus'' in Latin, was a mysterious and contagious disease that struck England and later continental Europe in a series of epidemics beginning ...

caused by

hantavirus ''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family '' Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses. Orthohantav ...

? * Was the Black Death due to bubonic plague? * Was "the great pox" syphilis or several venereal diseases? * Did King George III of the United Kingdom exhibit the classic symptoms of

porphyria Porphyria is a group of liver disorders in which substances called porphyrins build up in the body, negatively affecting the skin or nervous system. The types that affect the nervous system are also known as acute porphyria, as symptoms are ...

? * Were the conditions blamed on witches at the

Salem witch trials The Salem witch trials were a series of hearings and prosecutions of people accused of witchcraft in colonial Massachusetts between February 1692 and May 1693. More than 200 people were accused. Thirty people were found guilty, 19 of whom w ...

caused by ergotism? * Did

Napoleon Napoleon Bonaparte ; it, Napoleone Bonaparte, ; co, Napulione Buonaparte. (born Napoleone Buonaparte; 15 August 1769 – 5 May 1821), later known by his regnal name Napoleon I, was a French military commander and political leader who ...

die from stomach cancer, or was he poisoned with

arsenic Arsenic is a chemical element with the symbol As and atomic number 33. Arsenic occurs in many minerals, usually in combination with sulfur and metals, but also as a pure elemental crystal. Arsenic is a metalloid. It has various allotropes, ...

? * Could

Franklin D. Roosevelt's paralytic illness Franklin D. Roosevelt, later the 32nd president of the United States from 1933 to 1945, began experiencing symptoms of a paralytic illness in 1921 when he was 39 years old. His main symptoms were fever; symmetric, ascending paralysis; facial par ...

have been

Guillain–Barré syndrome Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain oft ...

rather than poliomyelitis? * Did

Abraham Lincoln Abraham Lincoln ( ; February 12, 1809 – April 15, 1865) was an American lawyer, politician, and statesman who served as the 16th president of the United States from 1861 until his assassination in 1865. Lincoln led the nation thro ...

have Marfan syndrome? * Did

Karl Marx Karl Heinrich Marx (; 5 May 1818 – 14 March 1883) was a German philosopher, economist, historian, sociologist, political theorist, journalist, critic of political economy, and socialist revolutionary. His best-known titles are the 1848 ...

have

hidradenitis suppurativa Hidradenitis suppurativa (HS), sometimes known as acne inversa or Verneuil's disease, is a long-term dermatological condition characterized by the occurrence of inflamed and swollen lumps. These are typically painful and break open, releasing ...

? * Could

Burke and Wills The Burke and Wills expedition was organised by the Royal Society of Victoria in Australia in 1860–61. It consisted of 19 men led by Robert O'Hara Burke and William John Wills, with the objective of crossing Australia from Melbourne in the ...

have died of

thiaminase Thiaminase is an enzyme that metabolizes or breaks down thiamine into two molecular parts. It is an antinutrient when consumed. The old name was "aneurinase". There are two types: * Thiamine pyridinylase, Thiaminase I (, ) * Aminopyrimidine am ...

poisoning? * Did

René Descartes René Descartes ( or ; ; Latinized: Renatus Cartesius; 31 March 1596 – 11 February 1650) was a French philosopher, scientist, and mathematician, widely considered a seminal figure in the emergence of modern philosophy and science. Ma ...

have Exploding head syndrome?

Retrospective diagnoses of autism

There have been many published speculative retrospective diagnoses of autism of historical figures. English scientist

Henry Cavendish Henry Cavendish ( ; 10 October 1731 – 24 February 1810) was an English natural philosopher and scientist who was an important experimental and theoretical chemist and physicist. He is noted for his discovery of hydrogen, which he termed "infl ...

is believed by some to have been autistic. George Wilson, a notable chemist and physician, wrote a book about Cavendish entitled ''The Life of the Honourable Henry Cavendish'' (1851), which provides a detailed description that indicates Cavendish may have exhibited many classic signs of autism. Sacks, Oliver
Henry Cavendish: An early case of Asperger's syndrome?
Neurological Foundation of New Zealand (Reprinted with permission from the American Neurological Association). Retrieved on 28 June 2007. The practice of retrospectively diagnosing autism is controversial. Professor Fred Volkmar of

Yale University Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United Sta ...

is not convinced; he claims that "There is unfortunately a sort of cottage industry of finding that everyone has Asperger's."

Historical research

Postmortem diagnosis

Examples

Retrospective diagnoses of autism

See also

References

Further reading